1、前列地爾在外科手術中的應用Masui. 1996 Mar;45(3):304-8.Effects of p rostagla ndin E1 onpl asma cytok ine levels duri ngpn eum on ectomy前列腺素E1對肺切除術后血漿細胞因子水平的影響。Article in Japan eseMatsumoto Y , Taniguchi T , Yoneda T , Mori I, Kobayashi H , Yamamoto K ,Kobayashi T .Dep artme nt of An esthesiology & Inten sive

2、Care Medici ne, Kan azawaUni versity, Ishikawa, Japan.AbstractWe inv estigated the effect of p rostagla ndin E1 (P GE1) on intraop erative cytok ineres pon sesand the in cide neeof p ost op erativecomp licati ons. Twen ty-six p atie nts un derg oing electivepn eum on ectomywere ran domly allocated i

3、nto P GE1 group (n = 12) and con trol group (n = 14).The P GE1 group received continu ous in fusi on of P GE1 duri ng surgery at a dose of 0.02-0.03 microgram.kg-1. min-1. Blood samp les were obta ined afterin duct ionof gen eralan esthesia,one and two hours after in cisi on,and immediately after th

4、e end of surgery to measure the p lasma levels of tumor n ecrosis factor-a Ipha (TNF-a Ip ha), i nterleuk in-6 (IL-6) and in terleuk in-8 (I L-8). Levels of CRP for two days after the surgery werein cisi onmeasured and p ost op erative comp licati ons were recorded. Levels ofTNF-al pha rose from 1.6

5、 p g.ml-1 (mea n) to 4.8 p g.ml-1 two hr after in the con trol group, while the level was supp ressed in the P GE1 group (P < 0.05). No sig ni fica nt differe nee was found in IL-6 levels betwee n the two groups. The IL-8 in creased duri ng surgery in both groups but the in crease wassig nifica n

6、tly less in the P GE1 group (P < 0.05). There was no differe nee inCRP, and no severe p ost op erative comp licatio n was observed. We con clude that P GE1 adm ini strati on supp resses TNF-a Ipha and IL-8 res pon ses duri ng pn eum on ectomy, but its effects on IL-6 and the p ost op erative stat

7、us were not sig nifica nt.PMID: 8721128 P ubMed - i ndexed for MEDLINE研究前列腺素E1對手術中細胞因子的影響以及對手術后并發癥的作用。將26位肺切除病人分為兩組：PGE1組和對照組。PGE1組在手術中持續灌注PGE120-30ug/kg.min ，之后取血樣，測TNF腫瘤壞死因子的水平， 白介素-6(IL-6)， 白介素-8(IL-8)，手術后兩天測CRP的水平。對照組，手術后兩小時 TNF水平 由 1.6 pg.ml-1 (mean) to 4.8 pg.ml-1 ，但是在 PGE1 組，升高的 TNF 被抑制。 但兩組的

8、白介素-6水平變化沒有顯著差異。白介素-8(1 L-8)在兩組均有升高，但 是PGE1組升高的幅度小于對照組。結論：前列腺素 E1減少TNF和白介素-8 在肺切除術中的生成。J Am Coll Surg. 1996 Oct;183 :371-6.htt p: /WWW. ncbi. nim. /pubmed/8843266P rostagla ndin E1 ameliorates decreased tracheal blood flow after esop hagectomy and aggressive upper mediast inal lymp hade necto

9、my for esop hageal carc ino ma.前列腺素E1可以改善食管癌食管切除術后和縱膈淋巴切除術后的食管血流。Hasegawa S , Imamura M , Shimada 丫，Kanda 丫 , Wada H , Hitomi S , Mori K.Dep artme nt of Critical Care Medici ne, Kyoto Un iversity Hos pital, Japan.AbstractBACKGROUND: Aggressive upper mediasti nal ly mp hade nectomy con tributes to a

10、better survival rate after esop hageal resecti on to treat esop hageal carc ino ma, but it also in creases p ost op erative res piratory comp licati ons.Devascularizati on of the airways because of mediast inal dissecti on is con sidered to be a cause of res piratory dysf un cti on. The p rese nt st

11、udy atte mpts to clarify whether or not tracheal blood flow (TBF) deteriorates after esop hagectomy an d, if so, whether or not in trave nous p rostagla ndin E1 (P GE1) atte nuates the deterioratio n. STUDY DESIGN: P atie nts un dergoi ng esop hagectomy and aggressive upper mediasti nal ly mp hade n

12、ectomy for the treatme nt of esop hageal carci noma (EC group, n = 12) or abdo minal surgery (con trol group, n = 6) were en rolled in this study. Measureme nt of TBF was p erformed using a laser Dopp ler flowmeter. Chan ges in TBF in duced by surgery and postop erative in trave nous P GE1 were stud

13、ied in both groups.RESULTS: The TBF deteriorated sig nifica ntly in the EC group (21.78 +/- 9.60 to 11.24 +/- 4.45 mL/mi nute/10(-1) kg, p = 0.002) but did n ot cha nge in the con trol group (26.13 +/- 6.84 to 26.61 +/- 4.69 mL/mi nute/10(-1) kg, p =0.7371). Postop erative in trave nous P GE1 p arti

14、ally, but sig nifica ntly, reversedthe deterioration in TBF in the EC group (11.53 +/- 4.58 to 14.87 +/- 6.30 mL/mi nu te/10(-1) kg, p = 0.0207) but did not effect the con trol group (29.41 +/7.89 to 29.41 +/- 8.79 mL/mi nute/10(-1) kg, p = 0.9989). CONCLUSIONS:Esop hagectomy and aggressive upper me

15、diasti nal ly mp hade nectomy cause a deteriorati on in TBF that is p artially atte nu ated by P GE1.PMID: 8843266 P ubMed - i ndexed for MEDLINEMasui. 2002 Apr;51(4):377-81.htt p: /WWW .n cbi. nim.n ih.go v/p ubmedEffect of p rostagla ndin E1 in fusi on duri ng and after total hip arthr opl asty un

16、 der hypoten sive an esthesia on postop erative liver fun cti onand hemorrhage髖關節置換術麻醉容易引發肝損傷和肝出血， 前列地爾在手術中持續灌注可以預 防這一并發癥的發生Article in Japan eseIkeya K , Kume M , Sato H , Kashimoto S , Kumazawa T .Dep artme nt of An esthesia, Kofu Mun ici pal Hos pi tal, Kofu 400-0832.AbstractWe evaluated the effec

17、ts of p rostagla ndin E1 (P GE1) on the liver fun cti on and hemorrhage after total hip arthro plasty (THA). Twenty p atie nts with normal liver fun ctio n were ran domly divided into two groups. The p atie nts werean esthetized with spinal an esthesia using 0.5% bupi vaca ine 4 ml and ep idural an

18、esthesia. The lary ngeal mask was in serted after adm ini stratio ns of 1.5-2 mg.kg-1 of propofol and 0.8 mg.kg-1 of succi ny Icholi ne. PGE1 was in fused in the P GE1 group at a rate of 0.01 microgram.kg-1. min-1 (P GE1 group) duri ng and after the op erati on (30-40 hrs). GOT and GPT values were e

19、valuated before, and at the end of op erati on, and on 1,4 and 7 p ost op erative days in each group. The amount of hemorrhage was measured at the end of op erati on and on 1,2, 3 and 4 postop erative days in each group. GOT values on 1 and 4 postop erative days in P GE1 group were sig nifica ntly l

20、ower tha n those in the con trol group. GPT values on 1,4 and 7 p ost op erative days in P GE1 group were also sig nifica ntly lower tha n those in the con trol group. The amount of bleed ing duri ng the op erati on and p ost op erative hemorrhage did not differ sig nifica ntly betwee n the two grou

21、ps. These results suggest that P GE1 may p reve nt postop erative liver damage, but it may not affect the amount of postop erative bleedi ng.PMID: 11995344 P ubMed - in dexed for MEDLINEAn esth An alg. 1999 Feb;88(2):446-51.htt p: /WWW .n cbi. nim.ni h.go v/p ubmedThe effects of p rostagla ndin E1 o

22、n intraop erative temp erature cha nges and the in cide nee of p ost op erative shiveri ng duri ng deliberate mild hypo thermia for n eurosurgical p rocedures.前列腺素E1對腦神經外科術后病人寒戰和體溫改變的作用。Kawaguchi M , Inoue S , Sakamoto T , Kawaraguchi Y , Furuya H , Sakaki T .Dep artme nt of An esthesiology, Nara Me

23、dical Uni versity, Japan.AbstractWe inv estigated the effects of i.v. p rostagla ndin E1 (P GE1) on intraop erative cha nges of core temp erature and the in cide nee of p ost op erative shiveri ng in n eurosurgical p atie nts un derg oing deliberate mild hypo thermia. Eighty-three p atie nts were ra

24、n domly assig ned to one of three groups: p atie nts in the control group did not receive P GE1, whereas p atie nts in the P G20 group and P G50 group received PGE1 at a dose of 0.02 and 0.05 microg x kg(-1) x mi n(-1), resp ectively. The admi nistrati on of P GE1 was started just after the in ducti

25、 on of an esthesia and continued un til the end of an esthesia. An esthesia was maintained with n itrous oxide in oxyge n, sevoflura ne, and fentan yl. After the in duct ion of an esthesia, p atie nts were cooled using a water bla nket and a conv ective device bla nket. Tympanic membra ne temp eratu

26、re was maintained at 34.5 degrees C. During surgical wound closure, p atie nts were rewarmed.Intraop erative cha nges in tympan ic membra ne and ski n temp eratures and the in cide nee of postop erative shiveri ng were comp ared among groups.Demogra phic and intraop erative variables were similar am

27、ong groups. There were no sig nifica nt differe nces in tympanic temp eratures among groups at each point duri ng the op erati on. Ski n temp erature 30 min after rewarmi ng and just after tracheal extubatio n was sig nifica ntly lower in the P G20 group tha n in the P G50 group. Postop erative shiveri ng w