UP,ANDMEMBERSCADRESSHOEVOCATIONALDUEDILIGENCECOMBINEDUP,ENSURESUCCESSFULLYCOMPLETEDEARLYDETERMINEOFTHETARGETTASK,ENSURESUCCESSFULLYCOMPLETEDLEVELSLEADERSHIPGENERALTASK,ENSURESUCCESSFULLYCOMPLETEDPOVERTYSTORMINGANNUALTARGETTASK,ENSURESOCIALOVERALLHARMONYSTABLETHREE,COMPACTINGTHEMAINRESPONSIBILITIESANDSTRENGTHENTHE“TWO“LEADERSHIPOFEDUCATIONALORGANIZATIONSDOAGOODJOB“TWO“EDUCATIONWITHOUTASTRONGORGANIZATIONANDLEADERSHIPPARTYCONSTRUCTIONOFPARTYORGANIZATIONSATALLLEVELSSHOULDFIRMLYESTABLISHTHEMAINCONSCIOUSNESS,GRASPINGPARTYBUILDINGASTHEFIRSTRESPONSIBILITY,STRENGTHENLEADERSHIP,DEMONSTRABLE,SCIENTIFICTOENSURESOLIDEDUCATIONEFFECTIVELYFIRST,THELAYERSOFRESPONSIBILITYPARTYCOMMITTEESLEADINGPARTYGROUPTOSTUDYEDUCATIONASAMAJORPOLITICALTASK,PRIMARYRESPONSIBILITYFOREFFECTIVEIMPLEMENTATION,STRENGTHENLEADERSHIP,CAREFULLYGUIDINGTHESTEERING,DOAGOODJOBOVERALL,STUDYANDSOLVEPROBLEMSINATIMELYMANNERPROGRESSEVALUATIONBYTHEGRASSROOTSPARTYBUILDINGTHISYEAR,TOSTUDYEDUCATIONASTHEPRIMARYEVALUATIONORGANIZATIONS,POORORGANIZATION,THEPROBLEMSAREMANY,TOCRITICIZE,TOACCOUNTABILITYMAINISRESPONSIBLEFORCOMRADETOCONSCIOUSLYBEARUPFIRSTRESPONSIBILITYPEOPLEDUTIES,NOTONLYTOTUBEGOODCADRES,ANDWITHGOODTEAM,ALSOTOTUBEGOODMEMBERS,ANDWITHGOODTEAM,BOTHFIRSTEXAMPLES,LEADPARTICIPATEINLEARNINGEDUCATION,ANDBYQIANCOMMAND,INPUTENOUGHOFTIMEANDENERGY,STRENGTHENEDGUIDEANDCHECKSROLE,ONWORKPROGRAMMEPERSONALLYVALIDATION,ONIMPORTANTTASKPERSONALLYDEPLOYMENT,ONEXISTSPROBLEMTIMELYSOLUTION,THROUGHOUTPUTRESPONSIBILITYCARRYINSHOULDERSHANG,IMPROPER“SHUAISHOUZHANGGUI“THECOUNTYPARTYCOMMITTEEANDMUNICIPALPARTYCOMMITTEEMUNICIPALWORKERS,VARIOUSENTERPRISESANDINSTITUTIONS,COMMISSION,PARTYCOMMITTEESANDDEPARTMENTSINCHARGEOFINDUSTRYPRACTICE,DEVELOPSPECIFICIMPLEMENTATIONPLAN,ORGANIZINGSPECIALFORCESRESPONSIBLEFOREDUCATIONALWORKTOSTRENGTHENTHISUNITTOTHESYSTEMSTUDYANDEDUCATIONINTHEREGIONSPECIFICGUIDANCEORGANIZATIONDEPARTMENTS,ASTHELEADDEPARTMENT,TOSTRENGTHENTHEPLANNING,ORGANIZATION,COORDINATIONANDGUIDANCE,GOODDESIGN,DECOMPOSITION,EACHKEYACTIONTOIMPLEMENTCARRYOUTSTUDYANDEDUCATION,TORELYONSTRICTDOCREALGUIDE,PRESSURECONVEYINGLAYERUPONLAYER,STEPBYSTEP,COMPACTIONOFRESPONSIBILITYINSTEERINGTHESTEERINGMUSTPREVENTFORMALISM,CATCHTHEWAYTHETHINKINGOFPREVENTIONACTIVITIES,STUDYANDEDUCATION,PREVENTINGROUTINEASIDE,PREVENTSIMPLE,DOINGASMUCHASMEETINGNOTESTOJUDGETHEEDUCATIONALRESULTSTOTAKEREPORTS,CUSTOMIZEDRESEARCH,ATTENDINGTHEMEETING,RANDOMSPOTCHECKS,BRIEFINGSANDOTHERMEANS,TOFOCUSTHEPUSHGUIDETOGRASSROOTS,ONTHEPARTYBRANCH,INDEPTHUNDERSTANDINGOFEDUCATIONANDACTUALEFFECT,SUMUPFRESHEXPERIENCETOPROMOTEGRASSROOTS,TODETECTANDCORRECTTHESIGNSOFPROBLEMSPUBLICINFORMATIONDEPARTMENTSSHOULDPAYSPECIALATTENTIONTOPUBLICOPINION,INDEPTHINFORMATIONRELATINGTOPROVINCIAL,MUNICIPALANDCENTRALDECISIONSANDARRANGEMENTSTOPROMOTEEDUCATIONALEFFECTIVENESSANDPROGRESSOFTHETYPICALEXPERIENCE,ANDCREATEAGOODSOCIALATMOSPHERESECOND,PERSEVERINGINABOVERATESLEADINGBODIESATALLLEVELS,LEADERSHIP,LEADINGCADRESSHOULDTAKETHELEAD,ASAGOODEXAMPLE,ANDASKINGOTHERSTODOYOUFIRSTDOIT,ASKSOFOTHERSANDNOTTHEMSELVESDETERMINEDNOTTODO,FOREXAMPLEOFSUPERIORTOSUBORDINATE,TEAMLEADERFORTEAMMEMBERSFOREXAMPLE,LEVELTOLEVEL,LEVELWITHLEVELS,LAYERSOFDRIVENMODEL,LAYERUPONLAYER,FORMATIONOFTHESHOTS,THEOVERALLGENERALEFFECTOFLINKAGENEEDSTRESSEDOFIS,REGARDLESSOFWHATRANKS,ANDWHATPOSTOFMEMBERSLEADERS,ARETOTOGENERALMEMBERSIDENTITYPUTHIMSELFPENDULUMIN,SERIOUSLYIMPLEMENTATIONCENTRALANDPROVINCIAL,ANDMUNICIPALONLEARNINGEDUCATIONOFTHEREQUIREMENTS,STRICTLYIMPLEMENTATIONDOUBLEORGANISED,BASICSYSTEM,LEADLEARNINGDISCUSSION,LEADONEXPERIENCE,ANDTOLDPARTYLECTURE,ANDFORREPORT,LEADPARTICIPATEINORGANISEDWILL,ANDDEMOCRATICCOMMENTS,LEADSHOEVOCATIONALDUEDILIGENCE,ANDBASEDPOSTFORCONTRIBUTION,DO“FOURTOLDFOURHAS“OFQUALIFIEDCOMMUNIST,STRIVETOMAKESLEARNINGRESEARCHMOREINDEPTH,ANDCHECKPENDULUMPROBLEMMOREDEEP,TOREORGANIZETHEIMPLEMENTATIONOFMORERADICAL,AVANTGARDEMORERESPECTABLEIMAGE,THUSLEARNINGEDUCATIONEFFECTIVETHIRD,STRENGTHENTHEGUIDANCETHEEDUCATIONFORALLMEMBERS,LARGEPERSONNELBASE,WIDEFIELD,HIERARCHY,DIFFERENCE,ANDTODIFFERENTIATEBETWEENCOUNTIES,DEPARTMENTS,GRASSROOTSUNITS,ALLKINDSOFPARTYORGANIZATIONANDPARTYMEMBERBETWEENTHEACTUALCHARACTERISTICSOFHIERARCHICALCLASSIFICATIONPOSITIONSPUTFORWARDMEASURESTOPREVENT“FLOODIRRIGATION“TOHAVEOPERABLEEACHPARTYSHOULDDEVELOPSPECIFICPROGRAMMESANDSPECIFICMEASURES,EDUCATIONPRINCIPLESANDLEARNINGREQUIREMENTSINTOOPERATIONAL,ABLETOPUTINPLACEWAYSTOGRASPFROMTHESPECIFICWORK,HARD,CATCHINGFINEPRACTICE,WITHCONCRETERESULTSTOVERIFYTHEEDUCATIONALRESULTSSHOULDBETARGETEDDIFFERENTPARTYMEMBERSIDEOLOGICALTRENDSANDBEHAVIORS,DIFFERENTIALTREATMENTINEDUCATION,PRECISIONAPPLICATIONPOLICY,“KEYSTARTSLOCKS“,DOWNTOLEARNANDDOTHEMEASURESEACHPARTYMEMBER,ENABLINGTHEMTOACCESSTOEDUCATION,IMPROVE,MAKEPEOPLEFEELMEMBERSOFTHENEWCHANGESTOREFLECTTHEDIFFERENCENOUNIFORM,THOUSANDSOFPEOPLE,ANDGIVEEXPRESSIONDIFFERENCES,CHARACTERISTICSINDETERMININGTHELEARNINGWHENTHETOPICWASDISCUSSED,ACCORDINGTODIFFERENTCHARACTERISTICSANDEXISTINGPROBLEMSOFPARTYMEMBERS,BOTHCLOSELYLINKEDTOTHETHEME,ANDREALITY,LETPARTYMEMBERSLEARN,ONTHEUPDOQUALIFIEDCOMMUNISTOFSTANDARDALSOCANNOTUNIFORM,COUNTYABOVEMEMBERSLEADERSSTANDARDTOMOREHIGHMORESTRICT,TOINSISTEDLOYALTYCLEANPLAY,DOJIAOYULUTYPEOFGOODCADRESONCOUNTYFOLLOWINGTHEFIELDTHEINDUSTRYOFMEMBERSTO全面介紹地中海貧血地中海貧血又稱海洋性貧血，是一組遺傳性疾病。其發病機制是合成血紅蛋白的珠蛋白鏈減少或缺失導致血紅蛋白結構異常，這種含有異常血紅蛋白的紅細胞變形性降低，壽命縮短，可以提前被人體的肝脾等破壞，導致貧血甚至發育等異常，這種疾病也就是醫學上講的溶血性貧血。疾病分類地中海貧血按照受累的氨基酸鏈來分類，組成珠蛋白的肽鏈有4種，即、鏈，分別由其相應的基因編碼，這些基因的缺失或點突變可造成各種肽鏈的合成障礙，致使血紅蛋白的組分改變。通常將地中海貧血分為、和等4種類型，其中以和地中海貧血較為常見。也可按照一個或兩個基因缺損來分為輕型或重型地中海貧血。病因及發病機制本病是由于珠蛋白基因的缺失或點突變所致。1地中海貧血人類珠蛋白基因簇位于11P155。地中海貧血（簡稱地貧）的發生主要是由于基因的點突變，少數為基因缺失。基因缺失和有些點突變可致鏈的生成完全受抑制，稱為0地貧；有些點突變使鏈的生成部分受抑制，則稱為地貧。UP,ANDMEMBERSCADRESSHOEVOCATIONALDUEDILIGENCECOMBINEDUP,ENSURESUCCESSFULLYCOMPLETEDEARLYDETERMINEOFTHETARGETTASK,ENSURESUCCESSFULLYCOMPLETEDLEVELSLEADERSHIPGENERALTASK,ENSURESUCCESSFULLYCOMPLETEDPOVERTYSTORMINGANNUALTARGETTASK,ENSURESOCIALOVERALLHARMONYSTABLETHREE,COMPACTINGTHEMAINRESPONSIBILITIESANDSTRENGTHENTHE“TWO“LEADERSHIPOFEDUCATIONALORGANIZATIONSDOAGOODJOB“TWO“EDUCATIONWITHOUTASTRONGORGANIZATIONANDLEADERSHIPPARTYCONSTRUCTIONOFPARTYORGANIZATIONSATALLLEVELSSHOULDFIRMLYESTABLISHTHEMAINCONSCIOUSNESS,GRASPINGPARTYBUILDINGASTHEFIRSTRESPONSIBILITY,STRENGTHENLEADERSHIP,DEMONSTRABLE,SCIENTIFICTOENSURESOLIDEDUCATIONEFFECTIVELYFIRST,THELAYERSOFRESPONSIBILITYPARTYCOMMITTEESLEADINGPARTYGROUPTOSTUDYEDUCATIONASAMAJORPOLITICALTASK,PRIMARYRESPONSIBILITYFOREFFECTIVEIMPLEMENTATION,STRENGTHENLEADERSHIP,CAREFULLYGUIDINGTHESTEERING,DOAGOODJOBOVERALL,STUDYANDSOLVEPROBLEMSINATIMELYMANNERPROGRESSEVALUATIONBYTHEGRASSROOTSPARTYBUILDINGTHISYEAR,TOSTUDYEDUCATIONASTHEPRIMARYEVALUATIONORGANIZATIONS,POORORGANIZATION,THEPROBLEMSAREMANY,TOCRITICIZE,TOACCOUNTABILITYMAINISRESPONSIBLEFORCOMRADETOCONSCIOUSLYBEARUPFIRSTRESPONSIBILITYPEOPLEDUTIES,NOTONLYTOTUBEGOODCADRES,ANDWITHGOODTEAM,ALSOTOTUBEGOODMEMBERS,ANDWITHGOODTEAM,BOTHFIRSTEXAMPLES,LEADPARTICIPATEINLEARNINGEDUCATION,ANDBYQIANCOMMAND,INPUTENOUGHOFTIMEANDENERGY,STRENGTHENEDGUIDEANDCHECKSROLE,ONWORKPROGRAMMEPERSONALLYVALIDATION,ONIMPORTANTTASKPERSONALLYDEPLOYMENT,ONEXISTSPROBLEMTIMELYSOLUTION,THROUGHOUTPUTRESPONSIBILITYCARRYINSHOULDERSHANG,IMPROPER“SHUAISHOUZHANGGUI“THECOUNTYPARTYCOMMITTEEANDMUNICIPALPARTYCOMMITTEEMUNICIPALWORKERS,VARIOUSENTERPRISESANDINSTITUTIONS,COMMISSION,PARTYCOMMITTEESANDDEPARTMENTSINCHARGEOFINDUSTRYPRACTICE,DEVELOPSPECIFICIMPLEMENTATIONPLAN,ORGANIZINGSPECIALFORCESRESPONSIBLEFOREDUCATIONALWORKTOSTRENGTHENTHISUNITTOTHESYSTEMSTUDYANDEDUCATIONINTHEREGIONSPECIFICGUIDANCEORGANIZATIONDEPARTMENTS,ASTHELEADDEPARTMENT,TOSTRENGTHENTHEPLANNING,ORGANIZATION,COORDINATIONANDGUIDANCE,GOODDESIGN,DECOMPOSITION,EACHKEYACTIONTOIMPLEMENTCARRYOUTSTUDYANDEDUCATION,TORELYONSTRICTDOCREALGUIDE,PRESSURECONVEYINGLAYERUPONLAYER,STEPBYSTEP,COMPACTIONOFRESPONSIBILITYINSTEERINGTHESTEERINGMUSTPREVENTFORMALISM,CATCHTHEWAYTHETHINKINGOFPREVENTIONACTIVITIES,STUDYANDEDUCATION,PREVENTINGROUTINEASIDE,PREVENTSIMPLE,DOINGASMUCHASMEETINGNOTESTOJUDGETHEEDUCATIONALRESULTSTOTAKEREPORTS,CUSTOMIZEDRESEARCH,ATTENDINGTHEMEETING,RANDOMSPOTCHECKS,BRIEFINGSANDOTHERMEANS,TOFOCUSTHEPUSHGUIDETOGRASSROOTS,ONTHEPARTYBRANCH,INDEPTHUNDERSTANDINGOFEDUCATIONANDACTUALEFFECT,SUMUPFRESHEXPERIENCETOPROMOTEGRASSROOTS,TODETECTANDCORRECTTHESIGNSOFPROBLEMSPUBLICINFORMATIONDEPARTMENTSSHOULDPAYSPECIALATTENTIONTOPUBLICOPINION,INDEPTHINFORMATIONRELATINGTOPROVINCIAL,MUNICIPALANDCENTRALDECISIONSANDARRANGEMENTSTOPROMOTEEDUCATIONALEFFECTIVENESSANDPROGRESSOFTHETYPICALEXPERIENCE,ANDCREATEAGOODSOCIALATMOSPHERESECOND,PERSEVERINGINABOVERATESLEADINGBODIESATALLLEVELS,LEADERSHIP,LEADINGCADRESSHOULDTAKETHELEAD,ASAGOODEXAMPLE,ANDASKINGOTHERSTODOYOUFIRSTDOIT,ASKSOFOTHERSANDNOTTHEMSELVESDETERMINEDNOTTODO,FOREXAMPLEOFSUPERIORTOSUBORDINATE,TEAMLEADERFORTEAMMEMBERSFOREXAMPLE,LEVELTOLEVEL,LEVELWITHLEVELS,LAYERSOFDRIVENMODEL,LAYERUPONLAYER,FORMATIONOFTHESHOTS,THEOVERALLGENERALEFFECTOFLINKAGENEEDSTRESSEDOFIS,REGARDLESSOFWHATRANKS,ANDWHATPOSTOFMEMBERSLEADERS,ARETOTOGENERALMEMBERSIDENTITYPUTHIMSELFPENDULUMIN,SERIOUSLYIMPLEMENTATIONCENTRALANDPROVINCIAL,ANDMUNICIPALONLEARNINGEDUCATIONOFTHEREQUIREMENTS,STRICTLYIMPLEMENTATIONDOUBLEORGANISED,BASICSYSTEM,LEADLEARNINGDISCUSSION,LEADONEXPERIENCE,ANDTOLDPARTYLECTURE,ANDFORREPORT,LEADPARTICIPATEINORGANISEDWILL,ANDDEMOCRATICCOMMENTS,LEADSHOEVOCATIONALDUEDILIGENCE,ANDBASEDPOSTFORCONTRIBUTION,DO“FOURTOLDFOURHAS“OFQUALIFIEDCOMMUNIST,STRIVETOMAKESLEARNINGRESEARCHMOREINDEPTH,ANDCHECKPENDULUMPROBLEMMOREDEEP,TOREORGANIZETHEIMPLEMENTATIONOFMORERADICAL,AVANTGARDEMORERESPECTABLEIMAGE,THUSLEARNINGEDUCATIONEFFECTIVETHIRD,STRENGTHENTHEGUIDANCETHEEDUCATIONFORALLMEMBERS,LARGEPERSONNELBASE,WIDEFIELD,HIERARCHY,DIFFERENCE,ANDTODIFFERENTIATEBETWEENCOUNTIES,DEPARTMENTS,GRASSROOTSUNITS,ALLKINDSOFPARTYORGANIZATIONANDPARTYMEMBERBETWEENTHEACTUALCHARACTERISTICSOFHIERARCHICALCLASSIFICATIONPOSITIONSPUTFORWARDMEASURESTOPREVENT“FLOODIRRIGATION“TOHAVEOPERABLEEACHPARTYSHOULDDEVELOPSPECIFICPROGRAMMESANDSPECIFICMEASURES,EDUCATIONPRINCIPLESANDLEARNINGREQUIREMENTSINTOOPERATIONAL,ABLETOPUTINPLACEWAYSTOGRASPFROMTHESPECIFICWORK,HARD,CATCHINGFINEPRACTICE,WITHCONCRETERESULTSTOVERIFYTHEEDUCATIONALRESULTSSHOULDBETARGETEDDIFFERENTPARTYMEMBERSIDEOLOGICALTRENDSANDBEHAVIORS,DIFFERENTIALTREATMENTINEDUCATION,PRECISIONAPPLICATIONPOLICY,“KEYSTARTSLOCKS“,DOWNTOLEARNANDDOTHEMEASURESEACHPARTYMEMBER,ENABLINGTHEMTOACCESSTOEDUCATION,IMPROVE,MAKEPEOPLEFEELMEMBERSOFTHENEWCHANGESTOREFLECTTHEDIFFERENCENOUNIFORM,THOUSANDSOFPEOPLE,ANDGIVEEXPRESSIONDIFFERENCES,CHARACTERISTICSINDETERMININGTHELEARNINGWHENTHETOPICWASDISCUSSED,ACCORDINGTODIFFERENTCHARACTERISTICSANDEXISTINGPROBLEMSOFPARTYMEMBERS,BOTHCLOSELYLINKEDTOTHETHEME,ANDREALITY,LETPARTYMEMBERSLEARN,ONTHEUPDOQUALIFIEDCOMMUNISTOFSTANDARDALSOCANNOTUNIFORM,COUNTYABOVEMEMBERSLEADERSSTANDARDTOMOREHIGHMORESTRICT,TOINSISTEDLOYALTYCLEANPLAY,DOJIAOYULUTYPEOFGOODCADRESONCOUNTYFOLLOWINGTHEFIELDTHEINDUSTRYOFMEMBERSTO地貧基因突變較多，迄今已發現的突變點達100多種，國內已發現28種。其中常見的突變有6種4142（TCTT，約占45；IVS654CT，約占24；17AT；約占14；TATA盒28AT，約占9；7172（A,約占2；26GA，即HBE26，約占2。重型地貧是0或地貧的純合子或0與地貧雙重雜合子，因鏈生成完全或幾乎完全受到抑制，以致含有鏈的HBA合成減少或消失，而多余的鏈則與鏈結合而成為HBFA22），使HBF明顯增加。由于HBF的氧親合力高，致患者組織缺氧。過剩的鏈沉積于幼紅細胞和紅細胞中，形成鏈包涵體附著于紅細胞膜上而使其變僵硬，在骨髓內大多被破壞而導致“無效造血”。部分含有包涵體的紅細胞雖能成熟并被釋放至外周血，但當它們通過微循環時就容易被破壞；這種包涵體還影響紅細胞膜的通透性，從而導致紅細胞的壽命縮短。由于以上原因，患兒在臨床上呈慢性溶血性貧血。貧血和缺氧刺激紅細胞生成素的分泌量增加，促使骨髓增加造血，因而引起骨骼的改變。貧血使腸道對鐵的吸收增加，加上在治療過程中的反復輸血，使鐵在組織中大量貯存，導致含鐵血黃素沉著癥。輕型地貧是0或地貧的雜合子狀態，鏈的合UP,ANDMEMBERSCADRESSHOEVOCATIONALDUEDILIGENCECOMBINEDUP,ENSURESUCCESSFULLYCOMPLETEDEARLYDETERMINEOFTHETARGETTASK,ENSURESUCCESSFULLYCOMPLETEDLEVELSLEADERSHIPGENERALTASK,ENSURESUCCESSFULLYCOMPLETEDPOVERTYSTORMINGANNUALTARGETTASK,ENSURESOCIALOVERALLHARMONYSTABLETHREE,COMPACTINGTHEMAINRESPONSIBILITIESANDSTRENGTHENTHE“TWO“LEADERSHIPOFEDUCATIONALORGANIZATIONSDOAGOODJOB“TWO“EDUCATIONWITHOUTASTRONGORGANIZATIONANDLEADERSHIPPARTYCONSTRUCTIONOFPARTYORGANIZATIONSATALLLEVELSSHOULDFIRMLYESTABLISHTHEMAINCONSCIOUSNESS,GRASPINGPARTYBUILDINGASTHEFIRSTRESPONSIBILITY,STRENGTHENLEADERSHIP,DEMONSTRABLE,SCIENTIFICTOENSURESOLIDEDUCATIONEFFECTIVELYFIRST,THELAYERSOFRESPONSIBILITYPARTYCOMMITTEESLEADINGPARTYGROUPTOSTUDYEDUCATIONASAMAJORPOLITICALTASK,PRIMARYRESPONSIBILITYFOREFFECTIVEIMPLEMENTATION,STRENGTHENLEADERSHIP,CAREFULLYGUIDINGTHESTEERING,DOAGOODJOBOVERALL,STUDYANDSOLVEPROBLEMSINATIMELYMANNERPROGRESSEVALUATIONBYTHEGRASSROOTSPARTYBUILDINGTHISYEAR,TOSTUDYEDUCATIONASTHEPRIMARYEVALUATIONORGANIZATIONS,POORORGANIZATION,THEPROBLEMSAREMANY,TOCRITICIZE,TOACCOUNTABILITYMAINISRESPONSIBLEFORCOMRADETOCONSCIOUSLYBEARUPFIRSTRESPONSIBILITYPEOPLEDUTIES,NOTONLYTOTUBEGOODCADRES,ANDWITHGOODTEAM,ALSOTOTUBEGOODMEMBERS,ANDWITHGOODTEAM,BOTHFIRSTEXAMPLES,LEADPARTICIPATEINLEARNINGEDUCATION,ANDBYQIANCOMMAND,INPUTENOUGHOFTIMEANDENERGY,STRENGTHENEDGUIDEANDCHECKSROLE,ONWORKPROGRAMMEPERSONALLYVALIDATION,ONIMPORTANTTASKPERSONALLYDEPLOYMENT,ONEXISTSPROBLEMTIMELYSOLUTION,THROUGHOUTPUTRESPONSIBILITYCARRYINSHOULDERSHANG,IMPROPER“SHUAISHOUZHANGGUI“THECOUNTYPARTYCOMMITTEEANDMUNICIPALPARTYCOMMITTEEMUNICIPALWORKERS,VARIOUSENTERPRISESANDINSTITUTIONS,COMMISSION,PARTYCOMMITTEESANDDEPARTMENTSINCHARGEOFINDUSTRYPRACTICE,DEVELOPSPECIFICIMPLEMENTATIONPLAN,ORGANIZINGSPECIALFORCESRESPONSIBLEFOREDUCATIONALWORKTOSTRENGTHENTHISUNITTOTHESYSTEMSTUDYANDEDUCATIONINTHEREGIONSPECIFICGUIDANCEORGANIZATIONDEPARTMENTS,ASTHELEADDEPARTMENT,TOSTRENGTHENTHEPLANNING,ORGANIZATION,COORDINATIONANDGUIDANCE,GOODDESIGN,DECOMPOSITION,EACHKEYACTIONTOIMPLEMENTCARRYOUTSTUDYANDEDUCATION,TORELYONSTRICTDOCREALGUIDE,PRESSURECONVEYINGLAYERUPONLAYER,STEPBYSTEP,COMPACTIONOFRESPONSIBILITYINSTEERINGTHESTEERINGMUSTPREVENTFORMALISM,CATCHTHEWAYTHETHINKINGOFPREVENTIONACTIVITIES,STUDYANDEDUCATION,PREVENTINGROUTINEASIDE,PREVENTSIMPLE,DOINGASMUCHASMEETINGNOTESTOJUDGETHEEDUCATIONALRESULTSTOTAKEREPORTS,CUSTOMIZEDRESEARCH,ATTENDINGTHEMEETING,RANDOMSPOTCHECKS,BRIEFINGSANDOTHERMEANS,TOFOCUSTHEPUSHGUIDETOGRASSROOTS,ONTHEPARTYBRANCH,INDEPTHUNDERSTANDINGOFEDUCATIONANDACTUALEFFECT,SUMUPFRESHEXPERIENCETOPROMOTEGRASSROOTS,TODETECTANDCORRECTTHESIGNSOFPROBLEMSPUBLICINFORMATIONDEPARTMENTSSHOULDPAYSPECIALATTENTIONTOPUBLICOPINION,INDEPTHINFORMATIONRELATINGTOPROVINCIAL,MUNICIPALANDCENTRALDECISIONSANDARRANGEMENTSTOPROMOTEEDUCATIONALEFFECTIVENESSANDPROGRESSOFTHETYPICALEXPERIENCE,ANDCREATEAGOODSOCIALATMOSPHERESECOND,PERSEVERINGINABOVERATESLEADINGBODIESATALLLEVELS,LEADERSHIP,LEADINGCADRESSHOULDTAKETHELEAD,ASAGOODEXAMPLE,ANDASKINGOTHERSTODOYOUFIRSTDOIT,ASKSOFOTHERSANDNOTTHEMSELVESDETERMINEDNOTTODO,FOREXAMPLEOFSUPERIORTOSUBORDINATE,TEAMLEADERFORTEAMMEMBERSFOREXAMPLE,LEVELTOLEVEL,LEVELWITHLEVELS,LAYERSOFDRIVENMODEL,LAYERUPONLAYER,FORMATIONOFTHESHOTS,THEOVERALLGENERALEFFECTOFLINKAGENEEDSTRESSEDOFIS,REGARDLESSOFWHATRANKS,ANDWHATPOSTOFMEMBERSLEADERS,ARETOTOGENERALMEMBERSIDENTITYPUTHIMSELFPENDULUMIN,SERIOUSLYIMPLEMENTATIONCENTRALANDPROVINCIAL,ANDMUNICIPALONLEARNINGEDUCATIONOFTHEREQUIREMENTS,STRICTLYIMPLEMENTATIONDOUBLEORGANISED,BASICSYSTEM,LEADLEARNINGDISCUSSION,LEADONEXPERIENCE,ANDTOLDPARTYLECTURE,ANDFORREPORT,LEADPARTICIPATEINORGANISEDWILL,ANDDEMOCRATICCOMMENTS,LEADSHOEVOCATIONALDUEDILIGENCE,ANDBASEDPOSTFORCONTRIBUTION,DO“FOURTOLDFOURHAS“OFQUALIFIEDCOMMUNIST,STRIVETOMAKESLEARNINGRESEARCHMOREINDEPTH,ANDCHECKPENDULUMPROBLEMMOREDEEP,TOREORGANIZETHEIMPLEMENTATIONOFMORERADICAL,AVANTGARDEMORERESPECTABLEIMAGE,THUSLEARNINGEDUCATIONEFFECTIVETHIRD,STRENGTHENTHEGUIDANCETHEEDUCATIONFORALLMEMBERS,LARGEPERSONNELBASE,WIDEFIELD,HIERARCHY,DIFFERENCE,ANDTODIFFERENTIATEBETWEENCOUNTIES,DEPARTMENTS,GRASSROOTSUNITS,ALLKINDSOFPARTYORGANIZATIONANDPARTYMEMBERBETWEENTHEACTUALCHARACTERISTICSOFHIERARCHICALCLASSIFICATIONPOSITIONSPUTFORWARDMEASURESTOPREVENT“FLOODIRRIGATION“TOHAVEOPERABLEEACHPARTYSHOULDDEVELOPSPECIFICPROGRAMMESANDSPECIFICMEASURES,EDUCATIONPRINCIPLESANDLEARNINGREQUIREMENTSINTOOPERATIONAL,ABLETOPUTINPLACEWAYSTOGRASPFROMTHESPECIFICWORK,HARD,CATCHINGFINEPRACTICE,WITHCONCRETERESULTSTOVERIFYTHEEDUCATIONALRESULTSSHOULDBETARGETEDDIFFERENTPARTYMEMBERSIDEOLOGICALTRENDSANDBEHAVIORS,DIFFERENTIALTREATMENTINEDUCATION,PRECISIONAPPLICATIONPOLICY,“KEYSTARTSLOCKS“,DOWNTOLEARNANDDOTHEMEASURESEACHPARTYMEMBER,ENABLINGTHEMTOACCESSTOEDUCATION,IMPROVE,MAKEPEOPLEFEELMEMBERSOFTHENEWCHANGESTOREFLECTTHEDIFFERENCENOUNIFORM,THOUSANDSOFPEOPLE,ANDGIVEEXPRESSIONDIFFERENCES,CHARACTERISTICSINDETERMININGTHELEARNINGWHENTHETOPICWASDISCUSSED,ACCORDINGTODIFFERENTCHARACTERISTICSANDEXISTINGPROBLEMSOFPARTYMEMBERS,BOTHCLOSELYLINKEDTOTHETHEME,ANDREALITY,LETPARTYMEMBERSLEARN,ONTHEUPDOQUALIFIEDCOMMUNISTOFSTANDARDALSOCANNOTUNIFORM,COUNTYABOVEMEMBERSLEADERSSTANDARDTOMOREHIGHMORESTRICT,TOINSISTEDLOYALTYCLEANPLAY,DOJIAOYULUTYPEOFGOODCADRESONCOUNTYFOLLOWINGTHEFIELDTHEINDUSTRYOFMEMBERSTO成僅輕度減少，故其病理生理改變極輕微。中間型地貧是一些地貧的雙重雜合子和某些地貧的變異型的純合子，或兩種不同變異型珠蛋白生成障礙性貧血的雙重雜合子狀態，其病理生理改變介于重型和輕型之間。2地中海貧血人類珠蛋白基因簇位于16PTERP133。每條染色體各有2個珠蛋基因，一對染色體共有4個珠蛋白基因。大多數地中海貧血（簡稱地貧）是由于珠蛋白基因的缺失所致，少數由基因點突變造成。若僅是一條染色體上的一個基因缺失或缺陷，則鏈的合成部分受抑制，稱為地貧；若每一條染色體上的2個基因均缺失或缺陷，稱為0地貧。重型地貧是0地貧的純合子狀態，其4個珠蛋白基因均缺失或缺陷，以致完全無鏈生成，因而含有鏈的HHA、HBA2和HBF的合成均減少。患者在胎兒期即發生大量鏈合成4（HBBARTS）。HBBARTS對氧的親合力極高，造成組織缺氧而引起胎兒水腫綜合征。中間型和地貧是0和地貧的雜合子狀態，是由3個珠蛋白基因缺失或缺陷所造成，患者僅能合成少量鏈，其多余的鏈即合成HBH（4）。HBH對氧親合力較高，又是一種不穩定血紅蛋白，容易在紅細胞內變性沉淀而形成包涵體，造成紅細胞膜僵硬而使紅細胞壽命縮短。輕型地貧是地貧純合子或0地貧雜合子狀態，UP,ANDMEMBERSCADRESSHOEVOCATIONALDUEDILIGENCECOMBINEDUP,ENSURESUCCESSFULLYCOMPLETEDEARLYDETERMINEOFTHETARGETTASK,ENSURESUCCESSFULLYCOMPLETEDLEVELSLEADERSHIPGENERALTASK,ENSURESUCCESSFULLYCOMPLETEDPOVERTYSTORMINGANNUALTARGETTASK,ENSURESOCIALOVERALLHARMONYSTABLETHREE,COMPACTINGTHEMAINRESPONSIBILITIESANDSTRENGTHENTHE“TWO“LEADERSHIPOFEDUCATIONALORGANIZATIONSDOAGOODJOB“TWO“EDUCATIONWITHOUTASTRONGORGANIZATIONANDLEADERSHIPPARTYCONSTRUCTIONOFPARTYORGANIZATIONSATALLLEVELSSHOULDFIRMLYESTABLISHTHEMAINCONSCIOUSNESS,GRASPINGPARTYBUILDINGASTHEFIRSTRESPONSIBILITY,STRENGTHENLEADERSHIP,DEMONSTRABLE,SCIENTIFICTOENSURESOLIDEDUCATIONEFFECTIVELYFIRST,THELAYERSOFRESPONSIBILITYPARTYCOMMITTEESLEADINGPARTYGROUPTOSTUDYEDUCATIONASAMAJORPOLITICALTASK,PRIMARYRESPONSIBILITYFOREFFECTIVEIMPLEMENTATION,STRENGTHENLEADERSHIP,CAREFULLYGUIDINGTHESTEERING,DOAGOODJOBOVERALL,STUDYANDSOLVEPROBLEMSINATIMELYMANNERPROGRESSEVALUATIONBYTHEGRASSROOTSPARTYBUILDINGTHISYEAR,TOSTUDYEDUCATIONASTHEPRIMARYEVALU