1、殼聚糖論文：殼聚糖的改性研究【中文摘要】本論文首先利用甲氧基聚乙二醇(mPEG)改善殼聚糖的水溶性。將不同分子量的mPEG的羥基羧化后,與殼聚糖分子鏈上3位羥基發(fā)生酯化反應(yīng),制備出梳形可分散于水的甲氧基聚乙二醇接枝殼聚糖(CS-g-mPEG)。采用紅外光譜(IR)、核磁共振(1H-NMR)對CS-g-mPEG的結(jié)構(gòu)進(jìn)行了表征,結(jié)果表明這種方法可以成功制備CS-g-mPEG。接枝共聚物水溶性實(shí)驗(yàn)表明,CS-g-mPEG接枝共聚物的溶解性得到顯著提高。為了改善殼聚糖的脂溶性,本論文在殼聚糖上面引入聚乳酸,殼聚糖上的羥基引發(fā)丙交酯開環(huán)聚合得到殼聚糖-聚乳酸(CS-g-PLA)接枝共聚物。采用紅外光譜

2、(IR)和核磁共振(1H-NMR)表征了接枝共聚物的結(jié)構(gòu)。共聚物的脂溶性實(shí)驗(yàn)表明,殼聚糖接枝聚乳酸后可以溶解在部分有機(jī)溶劑中。另外,本文還利用胺解技術(shù)在聚乳酸膜表面引入自由氨基,再利用戊二醛將氨基轉(zhuǎn)化為自由醛基,然后用殼聚糖涂層的方法,制備了殼聚糖表面改性的聚乳酸膜載體。采用紅外光譜(IR)對改性聚乳酸膜的結(jié)構(gòu)進(jìn)行分析表征。結(jié)果表明,殼聚糖可以成功固定在聚乳酸膜表面。殼聚糖接枝聚乳酸膜表面后可以改善聚乳酸的生物相容性。【英文摘要】Firstly, water solubility of the chitosan was improved by methoxy poly(ethylene gly

3、col)(mPEG) in this paper. mPEG with different molecular weights after carboxylated was occurred esterification reaction to the hydroxyl groups at C-3 on the chitosan backbone, and the comb-shaped methoxy poly(ethylene glycol) grafted chitosan(CS-g-mPEG) which can be dispersed in water was prepared.

4、The structure of CS-g-mPEG was characterized by infrared spectroscopy (IR) and nuclear magnetic resonance(H-NMR), and the results showed that CS-g-mPEG can be successfully prepared by this method. Water-soluble experiment of the graft copolymer showed that the solubility of the CS-g-mPEG graft copol

5、ymer was improved significantly.polylactide(PLA) was introduced to chitosan, and the graft copolymer of chitosan-g-polylactide(CS-g-PLA) was synthesized successfully through ringopening polymerization by the hydroxyl group of the chitosan initiated, in order to improve fat solubility. The structure

6、of this graft copolymer was characterized by IR and 1H-NMR. Fat-soluble experiment of the copolymer showed that chitosan grafted PLA can dissolve in partial organic solvents.In addition, in this paper, the free amino was introducd to the surface of the PLA membrane by using aminolysis technique, and

7、 amino group was transformed into adehyde group by using glutaraldehyde, then chitosan-modified PLA membrane was fabricated by chitosan-coating technique. The structure of the modified PLA was characterized by IR. The results showed that chitosan can be successfully fixed in the surface of the polyl

8、actide membrane. The biocompatibility of PLA can be improved after chitosan grafted the surface of PLA membrane.【關(guān)鍵詞】殼聚糖 接枝共聚物 甲氧基聚乙二醇 聚乳酸 丙交酯【英文關(guān)鍵詞】chitosan graft copolymer phthaloylchitosan poly(ethylene glycol)(mPEG) polylactide(PLA) Lactide【目錄】殼聚糖的改性研究摘要4-5ABSTRACT5第一章 緒論8-181.1 殼聚糖的簡介8-91.2 殼聚糖

9、的應(yīng)用9-111.2.1 殼聚糖在生物醫(yī)用材料方面的應(yīng)用9-101.2.2 殼聚糖在食品工業(yè)方面的應(yīng)用101.2.3 殼聚糖在造紙工業(yè)方面的應(yīng)用101.2.4 殼聚糖在紡織工業(yè)方面的應(yīng)用101.2.5 殼聚糖在吸附和螯合方面的應(yīng)用10-111.2.6 殼聚糖在環(huán)保方面的應(yīng)用111.3 殼聚糖的改性11-161.3.1 主鏈降解121.3.2 烷基化反應(yīng)121.3.3 酯化反應(yīng)12-131.3.4 醚化反應(yīng)131.3.5 ?；磻?yīng)13-141.3.6 殼聚糖的接枝改性14-151.3.7 希夫堿反應(yīng)151.3.8 羧基化反應(yīng)15-161.3.9 共混改性161.4 研究目的和意義及主要研究內(nèi)容1

10、6-18第二章 mPEG-g-CS的制備18-282.1 引言18-192.2 實(shí)驗(yàn)部分19-222.2.1 實(shí)驗(yàn)藥品及試劑192.2.2 實(shí)驗(yàn)儀器19-202.2.3 mPEG-g-CS的接枝共聚物的制備20-222.2.4 mPEG-g-CS的表征222.3 結(jié)果與討論22-272.3.1 PHCS的結(jié)構(gòu)表征22-242.3.2 mPEG-COOH的表征24-252.3.3 mPEG-g-CS的表征25-262.3.4 聚合物溶解性能實(shí)驗(yàn)26-272.4 本章小結(jié)27-28第三章 殼聚糖接枝聚乳酸共聚物28-383.1 引言28-293.2 實(shí)驗(yàn)部分29-323.2.1 實(shí)驗(yàn)藥品和儀器、實(shí)

11、驗(yàn)藥品干燥處理29-303.2.3 實(shí)驗(yàn)方法30-323.3 PLA-g-CS的表征323.3.1 傅里葉紅外光譜(IR)測試323.3.2 核磁共振波譜(NMR)分析323.3.3 聚合物的溶解性能實(shí)驗(yàn)323.4 結(jié)果與討論32-373.4.1 PHCS的結(jié)構(gòu)表征32-333.4.2 PLA-g-PHCS的表征33-353.4.3 PLA-g-CS的結(jié)構(gòu)表征35-363.4.4 聚合物的溶解性能實(shí)驗(yàn)36-373.5 本章小結(jié)37-38第四章 殼聚糖涂層聚乳酸膜的制備38-474.1 引言384.2 聚乳酸膜的制備及其改性38-404.3 實(shí)驗(yàn)部分40-414.3.1 實(shí)驗(yàn)藥品及試劑404.3.2 實(shí)驗(yàn)儀器40-414.4 實(shí)驗(yàn)方法41-424.4.1 PLA膜的制備414.4.2 聚乳酸的改性41-424.5 PLA-g-CS的表征42-434