1、常見腫瘤化療方案2004.10.30一、頭頸部癌1、DDP+5-FuCisplatin,“,2100mg/mi.v.(1h inf )d15-Fluorouracil21000mg/mi.v.(cont inf )d1-4(5)34周重復,也可附十放療前2、CBP+5-FuCarboplatin2300mg/mi.v.d15-Fluorouracil21000mg/mi.v.(cont inf )d1-434周重復3、IPIfosfamide 異環磷酰胺21500mg/mi.v.Mesna 保護d1-5Cisplatin10mg/m2i.v.(30min inf )d1-54周重復4、TIPP

2、aclitaxel (紫杉醇)2175mg/mi.v.(3h inf )d1Ifosfamide21000mg/mi.v.(2h, Mesna 保護)d1-3Cisplatin260mg/mi.v.d134周重復5、TICPaclitaxel2175mg/mi.v.(3h inf )d1Ifosfamide21000mg/mi.v.(2h, Mesna 保護)d1-3CarboplatinAUC=6i.v.(30min inf )d134周重復6、Docetaxel+CisplatinDocetaxel 多西紫杉醇2100mg/mi.v.11h inf )d1Cisplatin275mg/mi

3、.v.(3h inf )d13周重復7、Docetaxel+Cisplatin+5-Fluororacil(TPF)Docetaxel275mg/mi.v.d1Cisplatin2100mg/mi.v.d15-Fluorouracil21000mg/mi.v.(cont inf )d1-43周重復8、PBFCisplatin一, 2100mg/mi.v.(1h inf )d1Bleomycin 博來霉素15mgi.v.(bolus )d1 followed by216mg/mi.v.(cont inf )d1-55-Fluorouracil2650mg/mi.v.(cont inf )d1-5

4、4周重復9、BECCisplatin2100mg/mi.v.(1h inf )d1Epirubicin 表柔比星270mg/mi.v.(bolus )d1Bleomycin15mgi.v.(bolus )d1 followed by212mg/mi.v.(cont inf )d1-54周重復二、乳腺癌1、經典CMFCyclophosphamide (環磷2酰胺100mg/mp.o.d1-14Methotrexate (氨甲喋2吟40mg/mi.v.d1,85-Fluorouracil2600mg/mi.v.d1,84周重復2、改進CMFCyclophosphamide2600mg/mi.v.d

5、1Methotrexate240mg/mi.v.d15-Fluorouracil2600mg/mi.v.d13周重復3、ACDoxorubicin 阿霉素化2療藥物60mg/mi.v.d1Cyclophosphamide2600mg/mi.v.d1(,8)3周重復4、ECEpirubicin260mg/mi.v.d1Cyclophosphamide2600mg/mi.v.d13周重復5、IEIfosfamide22000mg/mi.v.Mesna 保護d1,8Epirubicin230mg/mi.v.d1,83周重復6、AC+TDoxorubicinCyclophosphamide“,260m

6、g/m 2600mg/mi.v.i.v.d1d13周重復,共4周期,然后Paclitaxel2175mg/mi.v. (3h inf )d13周重復,共4周期7、CAFCyclophosphamide2500mg/mi.v.d1Doxorubicin250mg/mi.v.d15-Fluorouracil2500mg/mi.v.d13周重復8、CEFCyclophosphamide2500mg/mi.v.d1Epirubicin2100mg/mi.v.d15-Fluorouracil2500mg/mi.v.d13周重復9、Paclitaxel 單藥Paclitaxel2175 或 200mg/m

7、i.v. (3h inf )d13周重復10、TADoxorubicin250mg/mi.v.d1Paclitaxel2220mg/mi.v. (3h inf )d2(ADM后 24h)3周重復11、Docetaxel 單藥Docetaxel275 或 100mg/mi.v. 11h inf )d13周重復或者Docetaxel240mg/mi.v. 11h inf )qw*4/6w3周重復12、Docetaxel+DoxorubicinDoxorubicin250mg/mi.v.d1Docetaxel275mg/mi.v. (1h inf )d13周重復13、Vinorelbine+Doxo

8、rubicinDoxorubicin一一.240-50mg/mi.v.d1Vinorelbine220-25mg/mi.v.d1,83周重復14、Capecitabine 單藥Capecitabine22510mg/mp.o.分兩次/天,3周重復15、Trastuzumab 單藥Trastuzumab4mg/kgi.v. (90 min inf )負荷量2mg/kgi.v. (30 min inf )維持量,qw三、肺癌一小細胞肺癌的化療SCLC1、CAOCyclophosphamide21000mg/mi.v.d1Doxorubicin (阿奇霉2素50mg/mi.v.d1Vincristi

9、ne2mgi.v.d13周重復2、CEVCyclophosphamide21000mg/mi.v.d1Epirubicin270mg/mi.v.d1Vincristine2mgi.v.d13周重復3、EPCisplatin280mg/mi.v. 11h inf )d1Etoposide2100mg/mi.v. (2h inf )d1-33周重復4、ECCarboplatin2300mg/mi.v.d1Etoposide2120mg/mi.v. (2h inf )d1-34周重復5、CAECyclophosphamide21000mg/mi.v.d1Doxorubicin240-50mg/mi.

10、v.d1Etoposide2100-120mg/mi.v. 11h inf )d1-33周重復d1-146、VIPEtoposide75mg/mi.v.d1-4Ifosfamide 21200mg/mi.v. (Mesna 保護)d1-4Cisplatin220mg/mi.v.d1-43周重復7、Topotecan 單藥Topotecan1.5mg/m2i.v. (30min inf )d1-53周重復8、Paclitaxel+CarboplatinPaclitaxel2175mg/mi.v. (3h inf )d1CarboplatinAUC=7i.v. (30min inf )d13周重復

11、二非小細胞肺癌的化療(NSCLC1、Docetaxel 單藥Docetaxel75mg/m2i.v. (1h inf )d13周重復2、Gemcitabine 單藥Gemcitabine21000-1250mg/m2i.v. (30min inf )d1,8,154周重復3、Vinorelbine 單藥Vinorelbine230mg/mi.v. (20min inf )d1,8,154周重復4、NPVinorelbine225mg/mi.v.d1,8,15Cisplatin2100mg/mi.v.d14周重復5、Paclitaxel+CisplatinPaclitaxel2175mg/mi.

12、v. (3h inf )d1Cisplatin280mg/mi.v. (1h inf )d13周重復6、 Paclitaxel+CarboplatinPaclitaxel2225mg/mi.v. (3h inf )d1CarboplatinAUC=6i.v.d13周重復7、Docetaxel+CisplatinDocetaxel-7廣 /二75mg/mi.v.diCisplatin75mg/mi.v.di3周重復8、Gemcitabine+CisplatinGemcitabine 21000mg/mi.v. (30-60min inf )d1,8,15Cisplatin2100mg/mi.v.

13、 (30-60min inf )di4周重復9、EPCisplatin2100mg/mi.v. (30-60min inf )diEtoposide2100mg/mi.v. (2h inf )di-33周重復四、食管癌1、DDP+5-FuCisplatin2100mg/mi.v. (2h inf )di5-Fluorouracil21000mg/mi.v. (cont inf )di-534周重復2、Paclitaxel+CisptatinPaclitaxel2180mg/mi.v. (3h inf )diCisplatin260mg/mi.v. (3h inf )di3周重復3、 TPEPa

14、clitaxel50mg/m2i.v. (1h inf )di,4Cisplatin215mg/mi.v. (1h inf )di,4Etoposide250mg/mi.v. (cont inf )di,4QW*3休息1周,4療程4、ECFEpirubicin50mg/m2i.v.diCisplatin260mg/mi.v.di5-Fluorouracil2200mg/mi.v. (cont inf )di-2i3周重復五、胃癌1 、 5-Fu+CF+DDPCisplatin250mg/mi.v. (1h inf )biwFolinic acid500mg/mi.v.(2h inf )qw*6

15、5-Fluorouracil . 22000mg/mi.v.(24h inf )qw*62、ECFEpirubicin250mg/mi.v.d1Cisplatin260mg/mi.v.d15-Fluorouracil2200mg/mi.v.(cont inf )d1-213周重復3、FAMTXMethotrexate211.5g/mi.v.d15-Fluorouracil21500mg/mi.v.d1Doxorubicin230mg/mi.v.d15Folinic acid15mg/m2p.o.MTX 24h, q6h*124周重復4、 ELFEtoposide2120mg/mi.v.(50m

16、in inf )d1-3Folinic acid2300mg/mi.v.(10min inf )d1-35-Fluorouracil2500mg/mi.v.(10min inf )d1-334周重復5 、 TCDocetaxel285mg/mi.v.(1h inf )d1Cisplatin275mg/mi.v.(1h inf )d13周重復六、大腸癌1、Mayo ClinicFolinic acid220mg/mi.v.(bolus )d1-55-Fluorouracil2425mg/mi.v.(bolus )d1-54周重復2、de GramontFolinic acid2200mg/mi.

17、v.(2h inf )d1-25-Fluorouracil2400mg/mi.v.(bolus )d1-22600mg/mi.v.(22h inf )d1-22周重復3、 Irinotecan MonotherapyIrinotecan2125mg/mi.v.(90min inf )qw*46周重復或者Irinotecan .2300-350mg/mi.v.(90min inf )d13周重復4、FOLFORIIrinotecan2125mg/mi.v.(90min inf )qw*4Folinic acid20mg/m2i.v.(bolus )qw*45-Fluorouracil2500mg

18、/mi.v.(bolus )qw*46周重復或者Irinotecan2180mg/mi.v.(90min inf )d1Folinic acid2200mg/mi.v.(2h inf )d1-25-Fluorouracil2400mg/mi.v.(bolus )d1-22600mg/mi.v.(22h inf )d1-22周重復5、Irinotecan+OxaliplatinIrinotecan2200mg/mi.v.(30min inf )d1Oxaliplatin285mg/mi.v.(2h inf )d13周重復6、Oxaliplatin MonotherapyOxaliplatin21

19、30mg/mi.v.(2h inf )d13周重復7、FOLFOX4Oxaliplatin285mg/mi.v.(2h inf )d1Folinic acid2200mg/mi.v.(2h inf )d1-25-Fluorouracil2400mg/mi.v.(bolus )d1-22600mg/mi.v.(22h inf )d1-22周重復8、FOLFOX6Oxaliplatin2100mg/mi.v.(2h inf )d1Folinic acid2400mg/mi.v.(2h inf )d15-Fluorouracil2400mg/mi.v.(bolus )d1-2224003000mg/

20、mi.v.(46h inf )d1-22周重復9、RaltitrexedRaltitrexed3mg/mi.v.d13周重復10、CapecitabineCapecitabine21250mg/mp.o.bid*143周重復11、UFT+CFUFT2100mg/mp.o.tid*28Folinic acid230mg/mp.o.tid*285周重復七、胰腺癌1、Gemcitabine2Gemcitabine 1000mg/mi.v. ( 30min inf )qw*7;休息1周后每周1次,連用3周,4療程2、5-Fluorouracil5-Fluorouracil2500mg/mi.v.(bo

21、lus )d1-54周重復3、 CF+5-FuFolinic acid220mg/mi.v. (2h inf )d1-55-Fluorouracil2425mg/mi.v. (bolus)d1-54周重復4、 Gemcitabine+CF+5-FuGemcitabine21000mg/mi.v. (30min inf)d1,8,15,22Folinic acid2200mg/mi.v. (2h inf )d1,8,15,225-Fluorouracil2750mg/mi.v. (cont inf )d1,8,15,226周重復八、膽管癌1、5-Fluorouracil5-Fluorouraci

22、l2500mg/mi.v.d1-54周重復或者5-Fluorouracil2600mg/mi.v.d1,8,154周重復2、GemcitabineGemcitabine21000mg/mi.v. (30min inf)d1,8,154周重復3、GemcitabineGemcitabine 22200mg/mi.v.(30min inf)di2周重復4、DocetaxelDocetaxel, V,2100mg/mi.v.(1h inf )d13周重復5、FLMFolinic acid2200mg/mi.v.d1-45-Fluorouracil2400mg/mi.v.d1-4Mitomycin28

23、mg/mi.v.d14周重復6、5-Fu+IFN-a5-Fluorouracil2750mg/mi.v.(cont inf :d1-5Interferon alpha5*10 6IUs.c.d1,3,52周重復九、宮頸癌1、IP2i.v.(24h inf ,Mesna 保Ifosfamide5000mg/m護d1Cisplatin250mg/mi.v.d13周重復2、IC2i.v.(24h inf ,Mesna 保Ifosfamide5000mg/m護esnad1Carboplatin2300mg/mi.v.d14周重復3、 BIPBleomycin230mg/mi.v.(24h inf )d

24、12i.v.(24h inf ,Mesna 保Ifosfamide5000mg/m護d2Cisplatin250mg/mi.v.d24周重復4、TIPPaclitaxel2175mg/mi.v.(3h inf )d12i.v.(24h inf ,MesnaIfosfamide5000mg/m護d2CisplatinLC,250mg/mi.v.d24周重復5、TPPaclitaxel2135mg/mi.v.(24h inf )d1Cisplatin25075mg/mi.v.d23周重復6、PFCisplatin275mg/mi.v.d15-Fluorouracil21000mg/mi.v.(co

25、nt inf )d1-43周重復,也可同時合并放療十、子宮內膜癌1、APDoxorubicin260mg/mi.v.d1Cisplatin5060mg/m2i.v.d13周重復2、TCPaclitaxel2175mg/mi.v.(3h inf )d1CarboplatinAUC=57i.v.(30min inf )d13周重復3、 PCDDoxorubicin245mg/mi.v.d1Paclitaxel2160mg/mi.v.(3h inf )d1Cisplatin260mg/mi.v.(1h inf )d13周重復,G-CSF支持廣、卵巢癌一線化療1、TPPaclitaxel2135mg/

26、mi.v.(3h 或 24h inf )d1Cisplatin75mg/m2i.v.(1mg/min)d1 或 d23周重復2、TCPaclitaxel2175mg/mi.v.(3h inf )d1CarboplatinAUC=56i.v.(1h inf )d13周重復3、CBP+CTXCyclophosphamide 2600mg/mi.v.d1Carboplatin2300mg/mi.v.(1h inf )d14周重復挽救治療1、TopotecanTopotecan21.01.5mg/mi.v.(30min inf )d1-53周重復2、EtoposideEtoposide250100mg

27、/mp.o.d1-143周重復3、 GemcitabineGemcitabine28001250mg/mi.v.30min inf )d1,8,154周重復4、IfosfamideIfosfamide2i.v.30min2h inf,Mesna 一 一12002400mg/m2保護d1-534周重復或者Ifosfamide2i.v. (con inf . Mesna 保1000mg/m護d1-74周重復5、IPIfosfamide21500mg/mi.v. (1h inf , Mesna保護)d2-5Paclitaxel2175mg/mi.v. (3h inf )d13周重復6、IM2i.v.

28、 (30min inf ,MesnaIfosfamide2000mg/m保護d1-3Mitoxantrone210mg/mi.v. (30min inf )d134周重復7、脂質體ADM脂質體ADM250mg/mi.v. (1h inf )d14周重復十二、絨毛膜癌低危1、MethorexateMethorexate0.40.6mg/kgi.m.或 i.v. (bolus )d1-5周重復2、DactinomycinDactinomycin1012ug/kgi.v.(bolus )d1-5周重復高危1、EMA-COEtoposide.一.2100mg/mi.v.11h inf )d1-2Met

29、horexate2100mg/mi.v.d12200mg/mi.v.(12h inf )d1Dactinomycin20.5mg/mi.v.(bolus )d1-2Cyclophosphamide2600mg/mi.v.(30min inf )d8Vincristine21.0mg/mi.v.(bolus )d83周重復2、 MACMethorexate0.3mg/kgi.m.d1-5Dactinomycin810ug/kgi.v.(bolus )d1-5Cyclophosphamide250mgi.v.(bolus )d1-5Chlorambucil0.2mg/kgp.o.d1-523周重復

30、3周重復3、挽救治療低危1、EAEtoposide2100mg/mi.v.11h inf )d1-3Dactinomycin20.5mg/mi.v.(bolus )d1-310大重復高危1、EP/EMAEPEtoposide2150mg/mi.v.(30min inf )d1Cisplatin275mg/mi.v.(4h inf )d1EMAEtoposide,“,2100mg/mi.v. (30min inf)d1Methorexate . 2300mg/mi.v. 112h inf )d1Dactinomycin0.5mgi.v. (bolus )d1Folinic acid15mgbid

31、 ,p.o.或 i.m.(MT新 24h, q6h*4 )d2,3EP/EMA每周交替十三、生殖細胞惡性腫瘤一非精原細胞瘤1、BEPBleomycin230mg/mi.v.b bolus )d1,8,15Etoposide2100mg/mi.v.(1h inf )d1-5或 165mg/mi.v.(1h inf )d1-3Cisplatin250mg/mi.v.d1-2或 20mg/n2i.v.d1-53周重復2、ACEDactinomycin0.5mgi.v.(bolus )d1-3Cyclophosphamide2500mg/mi.v.(30min inf )d3Etoposide2100

32、mg/mi.v.(1h inf )d1-34周重復3、VIPEtoposide2200mg/mi.v.(1h inf )d1-5Ifosfamide21600mg/mi.v.(1h inf , Mesna 保護) d1-5Cisplatin230mg/mi.v.(1h inf )d1-53周重復,G-CSF支持4、 T-BEPPaclitaxel2175mg/mi.v.(1h inf )d1Bleomycin30mgi.v.(bolus )d1,8,15Etoposide2200mg/mi.v.(1h inf )d1-5Cisplatin230mg/mi.v.(1h inf )d1-53周重復

33、,G-CSF支持5、VeIPVinblastine0.11mg/kgi.v.(bolus )d1-22i.v.(1h inf , MesnaIfosfamide1200mg/m保護d15Cisplatin20mg/m2i.v.3 30min inf )d153周重復6、TIPPaclitaxel 2250mg/mi.v.(24h inf )d1Ifosfamide21200mg/mi.v.(1h inf , Mesna 保護) d2-6Cisplatin220mg/mi.v.30min inf)d2-63周重復,G-CSF支持二精原細胞瘤EP1、BEPEtoposide2100mg/mi.v.

34、(1h inf )d1-5Cisplatin220mg/mi.v.30min inf)d1-53周重復2、VeIPVinblastine0.11mg/kgi.v.(bolus )d1-2Ifosfamide21200mg/mi.v.保護)(1h inf ,Mesnad15Cisplatin220mg/mi.v.30min inf)d153周重復十四、原發不明轉移瘤1 、 TCEPaclitaxel2200mg/mi.v.(1h inf )d1CarboplatinAUC=6i.v.2030mininf )d1Etoposide50mgp.o.d1,3,5,7,9100mgp.o.d2,4,6,

35、8,103周重復2、PEBBleomycin30mgi.v.(bolus )d1,8,15Etoposide2100mg/mi.v.(1h inf )d1-5Cisplatin220mg/mi.v.d153周重復3、 DCDocetaxel265mg/mi.v.d1CarboplatinAUC=6i.v.d13周重復4、TFLPaclitaxel.L,2175mg/mi.v.(3h inf )d1Folinic acid300mgi.v.(3060min inf)d1-35-Fluorouracil2350mg/mi.v.(3060min inf)d1-34周重復5、VACVinblastin

36、e1.4mg/m2i.v.d1Doxorubicin50mg/m2i.v.d1Cyclophosphamide2500mg/mi.v.d13周重復十五、惡性黑色素瘤1、DacarbazineDacarbazine28501000mg/mi.v.d1或者2250mg/mi.v.d1-534周重復2、FotemustineFotemustine2100mg/mi.v.(1h inf )d1,8,153周重復3、 VindesineVinblastine3mg/m2i.v.d12周重復,共1年；然后3周重復,共6月；最后4周重復,共6月4、低劑量IFNInterferon alpha3MUs.c.t

37、iw6-36 月5、中劑量IFNInterferon alpha10MUs.c.5天/周4周；然后5MUs.c.tiw2年6、高劑量IFNInterferon alpha20MU/m2i.v.或5天/周4周；然后2 10MU/m2s.c.tiw48周7、Interleukin-2Interleukin-2600000 或 720000IU/kgi.v.(15min)每8小時一次,共 14次,2周重復；假設耐殳,612周為一療程,最多5療程8、Dartmouth 方柔Cisplatin225mg/mi.v.(3045min inf)d1-3BCNU2150mg/mi.v.(short inf )

38、d1Dacarbazine220mg/mi.v.(short inf )d1-3Tamoxifen2040mgp.o.化療前1周開始3周重復9、DVPDacarbazine 2250mg/mi.v.(30min inf )d1-5Vindesine23mg/mi.v.(bolus )d1,8,15Cisplatin2100mg/mi.v.(30min inf )d14周重復10、Dacarbazine+Interferon alphaDacarbazine2800mg/mi.v.(short inf )d1Interferon alpha9MUs.c.tiw3周重復11、Dacarbazine

39、+Cisplatin+Interferon alpha+Interleukin-2Dacarbazine2250mg/mi.v.(30min inf )d1-3Cisplatin225mg/mi.v.(1h inf )d1-3Interferon alpha25MU/m2s.c.d6,8,10,13,15Interleukin-2218MU/m2i.v.(15min inf )d6-10,13-154周重復十六、惡性間皮瘤1、EpirubicinEpirubicin2110mg/mi.v.(bolus )d13周重復2、VinorelbineVinorelbine230mg/mi.v.(5min inf )qw6周升-療程3、APDoxorubicin60mg/m2i.v.(bolus )d1Cisplatin260mg/mi.v.(1h inf )d134周重復4、GPGemcitabine21000mg/mi.v.(30min inf )d1,8,15Cisplatin2100mg/mi.v.2h inf )d14周重復十七、神經內分泌癌1、DoxorubicinDoxorubicin“,260mg/mi.v.(bolus )d134周重復2