1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDASA-58Cat. No.: HY-19330CAS No.: 1203494-49-8分式: CHNOS分量: 453.53作靶點: Pyruvate Kinase作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數據體外實驗 DMSO : 35 mg/mL (77.17 mM)* means

2、 soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.2049 mL 11.0246 mL 22.0493 mL5 mM 0.4410 mL 2.2049 mL 4.4099 mL10 mM 0.2205 mL 1.1025 mL 2.2049 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗請根據您的實驗動物和給藥式選擇適當的溶解案，配制前請先配制澄清的儲備液，再依次添加助溶劑(為保證實驗結果的可靠性，體內實驗的作液，建議您

3、現現配，當天使；澄清的儲備液可以根據儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (4.59 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.08 mg/mL (4.59 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Maste

4、r of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.08 mg/mL (4.59 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 DASA-58是有效的丙酮酸激酶M2 (PKM2) 活化劑，其中AC90 和AC50分別為680 nM，38 nM。戶使本產品發表的科研獻 Nat Immunol. 2018 Mar;19(3):267-278. Arch Biochem Biophys. 2019 Jul 30;670:94-103.See more customer validations on HYPE

5、RLINK / www.MedChemEREFERENCES1. Palsson-McDermott EM, et al. Pyruvate kinase M2 regulates Hif-1 activity and IL-1 induction and is a critical determinant of thewarburg effect in LPS-activated macrophages. Cell Metab. 2015 Jan 6;21(1):65-80.2. Giannoni E, et al. Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastaticspread. Oncotarget. 2015 Sep 15;6(27):24061-24074.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-379