1、睡眠的生理學意義 消除疲勞、恢復體力 保護大腦、恢復精力提高機體的免疫力對兒童，睡眠有促進生長發育的特殊意義Nelson 兒科學，17版，2007；99Nelson 兒科學，17版，2007；99Nelson 兒科學，17版，2007；99 WATERS K A, Am J Med Genet, 1995, 59(4): 460-466.Hsueh-yu L, Chang Gung Med J,2009;32:24757AMERICAN THORACIC SOCIETY. Am J Respir Crit Care Med,1996, 153(2): 866-878. AMERICAN THO

2、RACIC SOCIETY. Am J Respir Crit Care Med,1996, 153(2): 866-878.OSAS in children is a disorder of breathing during sleepcharacterized by prolonged partial upper airway obstruction and/or intermittent complete obstruction(obstructive apnea)that disrupts normal ventilation during sleep and normal sleep

3、 patterns. It is associated with symptoms including habitual (nightly) snoring, sleep difficulties, and/or daytime neurobehavioral problems. Complications may include growth abnormalities, neurologic disorders, and cor pulmonale, especially in severe cases. Various risk factors have beenidentified a

4、nd are defined.Carolyn E I-L，AJRCCM，2007；175：436441OSAS對機體的影響Oscar S C，Proc Am Thorac Soc, 2008；5：274282Oscar S C，Proc Am Thorac Soc, 2008；5：274282Kahn A，Sleep,1993;16:409413Crouzon syndromeOscar S C，Proc Am Thorac Soc, 2008；5：274282Oscar S C，Proc Am Thorac Soc, 2008；5：274282蒙逖航,醫學綜述,2008;14(20):314

5、13143OSA引起心血管事件的細胞學機制Athanasios G，Chest，2008；134：324331A, adenoid; N, nasopharyngeal measurement; P,pharyngeal measurement; T, tonsil. T/P 0.479提示中重度OSA。A/N 0.74以上A M Li, Arch Dis Child 2002;87:156159 Liner LH, Curr Opin Pediatr,2006, 18(3): 272-276.S L Verhulst，Arch Dis Child 2006;91:233237Marcus C

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7、s，1994；93（5）：784788Gorur K,Int J Pediatr Otorhinolaryngol,2001,59(1):41-46.Basha S,Laryngoscope,2005,115(6):1101-1103.Mitchell Int JPediatrOtorhinolaryngol,2004,68 (11):1375-1379.張亞梅,王桂香.中國全科醫學, 2007, 10(2): 102-104.年幼兒因顱面生長快年幼兒因顱面生長快, ,應每應每6 6月評價月評價1 1次次不同年齡段nCPAP的成功率nCPAP簡便易行，依從性好，在多數病例可長期應用Massa F，Arch Dis Child，2002；87：438443FT 失敗例ST 成功例不同年齡段nCPAP的成功率Massa F，Arch Dis Child，2002；87：438443Craig AH，Neuropsychi Dis Treat，2006；2（3）：30926Craig AH，Neuropsychi Dis Treat，2006；2（3）：30926 Hoban TF,Neurologist,2005, 1