Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEZacopridehydrochloride(Standard)Cat.No.:HY-103137RCASNo.:101303-98-4分?式:C??H??Cl?N?O?分?量:346.25作?靶點(diǎn):5-HTReceptor作?通路:GPCR/GProtein;NeuronalSignaling儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Zacopride(hydrochloride)(Standard)Zacopride(hydrochloride)的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。Zacopridehydrochloride?種?效的5-HT3受體拮抗劑，5-HT3和5-HT4受體Kis值分別為0.38和373nM。Zacopridehydrochloride也?種中度的IK1通道激動劑。Zacopridehydrochloride具有顯的抗?律失常和?臟保護(hù)作?[1][2][3]。REFERENCES[1].NeumannJ,etal.Zacopridestimulates5-HT4serotoninreceptorsinthehumanatrium.NaunynSchmiedebergsArchPharmacol.2024Sep;397(9):6821-6835.[2].PinkusLM,etal.UtilizationofZacoprideanditsR-andS-EnantiomersinStudiesof5-HT3Receptor“Subtypes”.Serotonin:MolecularBiology,ReceptorsandFunctionalEffects,1991:439-448.[3].NagakuraY,etal.Pharmacologicalpropertiesofanovelgastrointestinalprokineticbenzamideselectiveforhuman5-HT4receptorversushuman5-HT3receptor.PharmacolRes.1999May;39(5):375-82.[4].SancilioLF,etal.Emeticactivityofzacoprideinferretsanditsantagonismbypharmacologicalagents.EurJPharmacol.1990Jun8;181(3):303-6.[5].McNeishCS,etal.The5-HT3antagonistzacoprideattenuatescocaine-inducedincreasesinextracellulardopamineinratnucleusaccumbens.PharmacolBiochemBehav.1993Aug;45(4):759-63.[6].J?k?l?P,etal.Theeffectsoftacrineandzacoprideontheperformanceofadultratsintheworkingmemorytask.GenPharmacol.1993May;24(3):675-9.[7].SancilioLF,etal.Studiesontheemeticandantiemeticpropertiesofzacoprideanditsenantiomers.EurJPharmacol.1991Jan17;192(3):365-9.[8].MeyerLC,etal.Zacoprideand8-OH-DPATreverseopioid-inducedrespiratorydepressionandhypoxiabutnotcatatonicimmobilizationingoats.AmJPhysiolRegulIntegrCompPhysiol.2006Feb;290(2):R405-13.1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[9].DunnRW,etal.Preclinicalanxiolyticversusantipsychoticprofilesofthe5‐HT3antagonistsondansetron,zacopride,3α‐tropanyl‐1H‐indole‐3‐carboxylicacidester,and1αH,3α,5αH‐tropan‐3‐yl‐3,5‐dichlorobenzoate.Drugdevelopmentresearch,1991,23(4):289-300.[10].CostallB,etal.Zacopride:anxiolyticprofileinrodentandprimatemodelsofanxiety.JPharmPharmacol.1988Apr;40(4):302-5.[11].KiiY,etal.Effectsof5-HT4-receptoragonists,cisapride,mosapridecitrate,andzacopride,oncardiacactionpotentialsinguineapigisolatedpapillarymuscles.JCardiovascPharmacol.1997May;29(5):670-5.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalappli