1、現(xiàn)代生物技術(shù)理論與實驗藥學(xué)中的生物技術(shù)和生物化學(xué)方法I - 生物技術(shù)緒論 藥學(xué)研究和應(yīng)用中的生物技術(shù)必備的生物學(xué)原理和知識本課程的教學(xué)安排現(xiàn)代藥物研發(fā)基本過程先導(dǎo)化合物候選藥物注冊藥物活性篩選臨床前評價藥物動力學(xué)性質(zhì)藥物毒性臨床I、II、III期評價藥物發(fā)現(xiàn)階段藥物開發(fā)階段化合物Integrated drug discovery/development paradigmPreclinicalDevelopmentClinicalDevelopmentDiscoveryResearchRecipe for Success!化學(xué)合成物生物技術(shù)制藥天然產(chǎn)物分離化合物庫制備藥物并行篩選&性質(zhì)研究優(yōu)化先

2、導(dǎo)/候選化合物 藥物構(gòu)效關(guān)系 藥物構(gòu)性關(guān)系 藥物構(gòu)毒關(guān)系新藥產(chǎn)品開發(fā)藥物臨床驗證藥物發(fā)現(xiàn)/開發(fā)合理藥物設(shè)計 基于結(jié)構(gòu) 基于機理 性質(zhì)改造藥學(xué)生物方法和生物技術(shù)Drug designStructural & molecular biological methodsDrug synthesis:Biotransformation and Synthetic BiologyDrug screening/evaluation:Biological molecule-based assaysCell-based assaysAnimal-based assaysRational drug deliver

3、yBiopharmaceutical methods藥物學(xué)家 必備素養(yǎng)Biology & Systems BiologyBiochemistryPharmaceutical ChemistryMedicinal chemistryEnvironmental Chemistry & Green synthesisChemical biologySynthetic biologyPharmacologyMolecular biochemistry教學(xué)安排崔景榮分子生物學(xué)技術(shù)蒲小平細胞培養(yǎng)及分析相關(guān)技術(shù)曾慧慧生物氧化和抗氧化劑篩選楊曉達：生物藥物技術(shù)免疫分析方法ADMET方法教材和習(xí)題PBL sem

4、inarPBL課堂的考試分?jǐn)?shù)占30%分組：本學(xué)期學(xué)生人數(shù)共118人。每組4人, 共27組，如本班不足4人的可與其他班學(xué)生組成4人每次seminar有78組的學(xué)生講述（105分鐘）每組針對一個問題，講15分鐘，其中講述12分鐘，提問3分鐘8.28各班交分組和選題名單，分組前請與崔景榮聯(lián)系;PPT的要求包括4方面內(nèi)容：問題的提出；解決問題的方法；采用現(xiàn)代技術(shù)的基本原理；總結(jié)并提出新的思路。第一次seminar的問題抗體和核酸適配子的分析化學(xué)非天然氨基酸標(biāo)記蛋白質(zhì)技術(shù)及其應(yīng)用Synthetic biology專題討論 Synthetic biology: overview

5、(innovations and possible downsides)Synthetic biology and organic synthesisSynthetic biology and drug discovery and biomedical applicationsSynthetic biology and metabolic engineeringSynthetic biology and biofuel一些啟發(fā)讀物for synthetic biologyMolecular Systems Biology 2:2006.0028，Synthetic biology: new e

6、ngineering rules for an emerging disciplineNature Reviews Molecular Cell Biology 10, 410-422 (June 2009), The second wave of synthetic biology: from modules to systemsNature Reviews Genetics 11, 367-379 (May 2010),Synthetic biology: applications come of ageScience 2 September 2011:Vol. 333 no. 6047

7、pp. 1244-1248,Synthetic Biology: Integrated Gene Circuits Nature 483, 29 (01 March 2012),Synthetic biology: Four steps to avoid a synthetic-biology disasterChemistry & Biodiversity,Volume 4, Issue 4, pages 603621, April 2007, Chemical Aspects of Synthetic BiologyNature Chemical Biology 3, 521 - 525

8、(2007),Synthetic biology: lessons from the history of synthetic organic chemistryCurrent Opinion in Biotechnology,Volume 20, Issue 4, August 2009, Pages 498503,Chemical synthesis using synthetic biologyChem. Soc. Rev. , 2010, 39, 286-300,Controlled polymer synthesisfrom biomimicry towards synthetic

9、biologyDrug Discovery Today,Volume 14, Issues 1920, October 2009, Pages 956963,The impact of synthetic biology on drug discovery Nature Biotechnology 29, 693695 (2011) , Synergies between synthetic biology and metabolic engineeringMetabolic Engineering,Volume 14, Issue 3, May 2012, Pages 189195,Synt

10、hetic Biology: New Methodologies and Applications for Metabolic EngineeringSynthetic biology and the development of tools for metabolic engineering Current Opinion in Biotechnology,Volume 19, Issue 6, December 2008, Pages 556563,Metabolic engineering of microorganisms for biofuels production: from b

11、ugs to synthetic biology to fuels Applied Microbiology and Biotechnology,March 2010, Volume 86, Issue 2, pp 419-434,Biofuel production in Escherichia coli: the role of metabolic engineering and synthetic biology Science 2 September 2011:Vol. 333 no. 6047 pp. 1248-1252,Synthetic Biology Moving into the Clinic Nature Reviews Genetics 13, 21-35 (January 2012) , Emerging biomedical applications of synthetic biology 2005 Nanotechnology 16 R1 doi:10.1088/0957-4484/16/1/R01, Synthetic biology for nanotechnology 2006 Molecular Systems Biology 2:69,Cell-fre