Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENarlaprevir(Standard)Cat.No.:HY-10300RCASNo.:865466-24-6Synonyms:SCH900518(Standard)分?式:C??H??N?O?S分?量:707.96作?靶點:HCV;HCVProtease;SARS-CoV作?通路:Anti-infection;MetabolicEnzyme/Protease儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Narlaprevir(Standard)Narlaprevir的分析標準品。本產品?于研究及分析應?。Narlaprevir(SCH900518)?種選擇性的且有?服活性的NS3protease抑制劑，Ki值為6nM，EC90值為40nM。Narlaprevir還抑制丙型肝炎病毒(HCV)?結構蛋?3絲氨酸蛋?酶。Narlaprevir可?于慢性丙型肝炎研究。Narlaprevir也是SARS-CoV3CLpro的抑制劑，IC50為2.3μM。IC50&TargetKi:6nM(NS3protease)[1]EC90:40nM(NS3protease)[1]Ki:7nM(ketoamide)[2]EC90:40nM(repliconRNA)[2]REFERENCES[1].AshokArasappan,etal.DiscoveryofNarlaprevir(SCH900518):APotent,SecondGenerationHCVNS3SerineProteaseInhibitor.ACSMedChemLett.2010Feb15;1(2):64-9.[2].XTong,etal.PreclinicalcharacterizationoftheantiviralactivityofSCH900518(narlaprevir),anovelmechanism-basedinhibitorofhepatitisCvirusNS3protease.AntimicrobAgentsChemother.2010Jun;54(6):2365-70.[3].QiSun,etal.Bardoxoloneandbardoxolonemethyl,twoNrf2activatorsinclinicaltrials,inhibitSARS-CoV-2replicationandits3C-likeprotease.SignalTransductTargetTher.2021May29;6(1):212.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax: