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1、 HYPERLINK https:/www.MedChemE/Targets/Urotensin Receptor.html Urotensin HYPERLINK https:/www.MedChemE/Targets/Urotensin Receptor.html HYPERLINK https:/www.MedChemE/Targets/Urotensin Receptor.html ReceptorUT receptorUrotensin receptor (UT) is a G-protein coupled receptor which binds the peptide horm
2、oneurotensin. The urotensin-II (UT) receptoris a Gq/11-protein-coupled receptor that mediates complex hemodynamic effects and influences neuromuscular physiology. TheUT receptor displays greatest expression levels in the peripheral vasculature, heart and kidney, although they are found elsewhere,not
3、ably the central nervous system, at lower levels. The UT receptor produces potent but variable vasoconstrictor effects in somevascular beds, yet mediates vasodilation in others; it has also been implicated in osmoregulation.www.MedChemE 1 HYPERLINK https:/www.MedChemE/Targets/Urotensin Receptor.html
4、 Urotensin HYPERLINK https:/www.MedChemE/Targets/Urotensin Receptor.html HYPERLINK https:/www.MedChemE/Targets/Urotensin Receptor.html Receptor HYPERLINK https:/www.MedChemE/Targets/Urotensin Receptor.html HYPERLINK https:/www.MedChemE/Targets/Urotensin Receptor.html Agonists, HYPERLINK https:/www.M
5、edChemE/Targets/Urotensin Receptor.html HYPERLINK https:/www.MedChemE/Targets/Urotensin Receptor.html Antagonists HYPERLINK https:/www.MedChemE/Targets/Urotensin Receptor.html HYPERLINK https:/www.MedChemE/Targets/Urotensin Receptor.html & HYPERLINK https:/www.MedChemE/Targets/Urotensin Receptor.htm
6、l HYPERLINK https:/www.MedChemE/Targets/Urotensin Receptor.html Activators HYPERLINK https:/www.MedChemE/Palosuran.html Palosuran(ACT-058362) Cat. No.: HY-10655 HYPERLINK https:/www.MedChemE/palosuran-hydrochloride.html Palosuran HYPERLINK https:/www.MedChemE/palosuran-hydrochloride.html HYPERLINK h
7、ttps:/www.MedChemE/palosuran-hydrochloride.html hydrochloride(ACT-058362 hydrochloride) Cat. No.: HY-10655APalosuran (ACT-058362) is a potent, selective, andorally active antagonist of urotensin II receptor,with an IC of 3.6 nM for CHO cell membranesexpressing human recombinant receptors. Palosuranc
8、an improves pancreatic and renal function indiabetic rats.Palosuran hydrochloride (ACT-058362 hydrochloride)is a potent, selective, and orally activeantagonist of urotensin II receptor, with an ICof 3.6 nM for CHO cell membranes expressing humanrecombinant receptors.Purity: 99.33%Clinical Data: No D
9、evelopment ReportedSize: 5 mg, 10 mg, 50 mg, 100 mgPurity: 98.67%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 5 mg, 10 mg, 50 mg HYPERLINK https:/www.MedChemE/sb-611812.html SB-611812 HYPERLINK https:/www.MedChemE/sb-611812.html HYPERLINK https:/www.MedChemE/sb-657510.html SB-657510Cat. N
10、o.: HY-10664 Cat. No.: HY-10656SB-611812 is a urotensin II receptor (UTR)antagonist with the potential in the treatment ofcardiovascular disease.SB-657510 is a selective urotensin II (UII)receptor (UT) antagonist. The K values are 61,17, 30, 65 and 56 nM for human, monkey, cat, ratand mouse receptor
11、s, respectively.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.84%Clinical Data: No Development ReportedSize: 10 mM 1 mL, 1 mg, 5 mg, 10 mg HYPERLINK https:/www.MedChemE/ufp-803.html UFP-803 HYPERLINK https:/www.MedChemE/ufp-803.html HYPERLINK https:/www.MedChemE/ufp-803
12、-tfa.html UFP-803 HYPERLINK https:/www.MedChemE/ufp-803-tfa.html HYPERLINK https:/www.MedChemE/ufp-803-tfa.html TFACat. No.: HY-P1166 Cat. No.: HY-P1166AUFP-803 is a potent urotensin-II receptor (UT)ligand. UFP-803 has lower residual agonistactivity, so it may be an important tool for theinvestigati
13、ons on the role played by the UTsystem in physiology and pathology.UFP-803 TFA is a potent urotensin-II receptor (UT)ligand. UFP-803 TFA has lower residual agonistactivity, so it may be an important tool for theinvestigations on the role played by the UTsystem in physiology and pathology.Purity: 98%
14、Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Urotensin_II_114-124_,_human.html Urotensin HYPERLINK https:/www.MedChemE/Urotensin_II_114-124_,_human.html HYPERLINK https:/www.MedChemE/Urotensin_II
15、_114-124_,_human.html II HYPERLINK https:/www.MedChemE/Urotensin_II_114-124_,_human.html HYPERLINK https:/www.MedChemE/Urotensin_II_114-124_,_human.html (114-124), HYPERLINK https:/www.MedChemE/Urotensin_II_114-124_,_human.html HYPERLINK https:/www.MedChemE/Urotensin_II_114-124_,_human.html human HY
16、PERLINK https:/www.MedChemE/Urotensin_II_114-124_,_human.html HYPERLINK https:/www.MedChemE/urotensin-ii-114-124-human-tfa.html Urotensin HYPERLINK https:/www.MedChemE/urotensin-ii-114-124-human-tfa.html HYPERLINK https:/www.MedChemE/urotensin-ii-114-124-human-tfa.html II HYPERLINK https:/www.MedChe
17、mE/urotensin-ii-114-124-human-tfa.html HYPERLINK https:/www.MedChemE/urotensin-ii-114-124-human-tfa.html (114-124), HYPERLINK https:/www.MedChemE/urotensin-ii-114-124-human-tfa.html HYPERLINK https:/www.MedChemE/urotensin-ii-114-124-human-tfa.html human HYPERLINK https:/www.MedChemE/urotensin-ii-114
18、-124-human-tfa.html HYPERLINK https:/www.MedChemE/urotensin-ii-114-124-human-tfa.html TFACat. No.: HY-P1164 Cat. No.: HY-P1164AUrotensin II (114-124), human, an 11-amino acidresidue peptide, is a potent vasoconstrictor andagonist for the orphan receptor GPR14.Urotensin II (114-124), human TFA, an 11
19、-aminoacid residue peptide, is a potent vasoconstrictorand agonist for the orphan receptor GPR14.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mgPurity: 99.76%Clinical Data: No Development ReportedSize: 1 mg, 5 mg HYPERLINK https:/www.MedChemE/Urotensin_II,_mouse.html Urotensin HYPE
20、RLINK https:/www.MedChemE/Urotensin_II,_mouse.html HYPERLINK https:/www.MedChemE/Urotensin_II,_mouse.html II, HYPERLINK https:/www.MedChemE/Urotensin_II,_mouse.html HYPERLINK https:/www.MedChemE/Urotensin_II,_mouse.html mouse HYPERLINK https:/www.MedChemE/Urotensin_II,_mouse.html HYPERLINK https:/ww
21、w.MedChemE/urotensin-ii-mouse-acetate.html Urotensin HYPERLINK https:/www.MedChemE/urotensin-ii-mouse-acetate.html HYPERLINK https:/www.MedChemE/urotensin-ii-mouse-acetate.html II, HYPERLINK https:/www.MedChemE/urotensin-ii-mouse-acetate.html HYPERLINK https:/www.MedChemE/urotensin-ii-mouse-acetate.
22、html mouse HYPERLINK https:/www.MedChemE/urotensin-ii-mouse-acetate.html HYPERLINK https:/www.MedChemE/urotensin-ii-mouse-acetate.html acetateCat. No.: HY-P1483 Cat. No.: HY-P1483BUrotensin II, mouse is an endogenous ligand forthe orphan G-protein-coupled receptor GPR14 orSENR. Urotensin II, mouse i
23、s a potentvasoconstrictor. Urotensin II, mouse plays aphysiological role in the central nervous system.Urotensin II, mouse acetate is an endogenousligand for the orphan G-protein-coupled receptorGPR14 or SENR. Urotensin II, mouse acetate is apotent vasoconstrictor. Urotensin II, mouseacetate plays a
24、 physiological role in the centralnervous system.Purity: 98%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mgPurity: 99.65%Clinical Data: No Development ReportedSize: 1 mg, 5 mg, 10 mg2 Tel: 609-228-6898 Fax: 609-228-5909 Email: salesMedChemE HYPERLINK https:/www.MedChemE/urotensin-ii-mo
25、use-tfa.html Urotensin HYPERLINK https:/www.MedChemE/urotensin-ii-mouse-tfa.html HYPERLINK https:/www.MedChemE/urotensin-ii-mouse-tfa.html II, HYPERLINK https:/www.MedChemE/urotensin-ii-mouse-tfa.html HYPERLINK https:/www.MedChemE/urotensin-ii-mouse-tfa.html mouse HYPERLINK https:/www.MedChemE/urotensin-ii-mouse-tfa.html HYPERLINK https:/www.MedChemE/urotensin-ii-mouse-tfa.html TFA HYPERLINK https:/www.MedChemE/urotensin-ii-mouse-tfa.html HYPERLINK https:/www.MedChemE/orn5-urp.html Orn5-URPCat. No.: HY-P1483A Cat. No.: HY-P1167Urotensin II, mouse TFA is an endogenous ligandfor t
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