1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemETAK-580Cat. No.: HY-15246CAS No.: 1096708-71-2Synonyms: MLN 2480; BIIB-024分式: CHClFNOS分量: 506.29作靶點: Raf作通路: MAPK/ERK Pathway儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 50 mg/mL (98.76

2、mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.9752 mL 9.8758 mL 19.7515 mL5 mM 0.3950 mL 1.9752 mL 3.9503 mL10 mM 0.1975 mL 0.9876 mL 1.9752 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬湟?，再依次添加助溶?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液

3、可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (4.94 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (4.94 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molec

4、ules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (4.94 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 TAK-580 (MLN 2480)種可服的，具有選擇性的譜的 Raf 抑制劑。IC50 & Target RAF體外研究 TAK-580 (MLN 2480) has effect on reversing feedback activation of MEK in response to TAK-733, leading tomore concerted MAPK pathway inhibition 1

5、.體內(nèi)研究 TAK-580 (MLN 2480) inhibits MAPK pathway signaling in BRAF mutant and some RAS mutant preclinicalcancer models at concentrations that are tolerated in vivo. TAK-580 (MLN 2480) is most potent in BRAFmutant melanoma models but also has single agent activity in some RAS mutant models. The combina

6、tion ofMLN2480 with TAK-733 inhibits the growth of a broader range of RAS mutant tumor models than singleagent TAK-580 (MLN 2480), including primary human tumor xenograft models of melanoma and CRC 1.戶使本產(chǎn)品發(fā)表的科研獻 Technical University of Munich. 24.01.2018.See more customer validations on HYPERLINK /

7、www.MedChemEREFERENCES1. Elizabeth Grace Carideo Cunniff, et al. Abstract C146: Combination treatment with the investigational RAF kinase inhibitor MLN2480and the investigational MEK kinase inhibitor TAK-733 inhibits the growth of BRAF mutant and RAS mutant preclinical models ofMcePdfHeightCaution: Product has not been fully validated for medical applications.For research us