1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEIndinavir sulfateCat. No.: HY-B0689ACAS No.: 157810-81-6Synonyms: MK-639 sulfate; L735524 sulfate分式: CHNOS分量: 711.87作靶點: HIV; HIV Protease作通路: Anti-infection; Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent

2、 -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實驗 DMSO : 100 mg/mL (140.48 mM)H2O : 50 mg/mL (70.24 mM; Need ultrasonic)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.4048 mL 7.0238 mL 14.0475 mL5 mM 0.2810 mL 1.4048 mL 2.8095 mL10 mM 0.1405 mL 0.7024 mL 1.4048 mL請根據(jù)產(chǎn)

3、品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實驗請根據(jù)您的實驗動物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬湟海僖来翁砑又軇?為保證實驗結(jié)果的可靠性，體內(nèi)實驗的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 3 mg/mL (4.21 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20%

4、SBE-CD in saline)1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 3 mg/mL (4.21 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oilSolubility: 3 mg/mL (4.21 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Indinavir(MK-639; L735524)硫酸鹽HIV蛋酶抑制劑，具有很好的服物相容性。REFERENCES1. Stein, D.S., et al., A 2

5、4-week open-label phase I/II evaluation of the HIV protease inhibitor MK-639 (indinavir). AIDS, 1996. 10(5): p. 485-92.2. Liu, F., et al., Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistantmutations L24I, I50V, and G73S. J Mol Biol, 2005. 354(4): p. 789-800.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 02