1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemELinoleic acidCat. No.: HY-N0729CAS No.: 60-33-3分式: CHO分量: 280.45作靶點: Endogenous Metabolite作通路: Metabolic Enzyme/Protease儲存式: Pure form -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數據體外實驗 DMSO : 43.33 mg/mL (154.5

2、0 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 3.5657 mL 17.8285 mL 35.6570 mL5 mM 0.7131 mL 3.5657 mL 7.1314 mL10 mM 0.3566 mL 1.7828 mL 3.5657 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗請根據您的實驗動物和給藥式選擇適當的溶解案，配制前請先配制澄清的儲備液，再依次添加助溶劑(為保證實驗結果的可靠性

3、，體內實驗的作液，建議您現現配，當天使；澄清的儲備液可以根據儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.17 mg/mL (7.74 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.17 mg/mL (7.74 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn

4、oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.17 mg/mL (7.74 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Linoleic acid多不飽和脂 酸的種關鍵組分。IC50 & Target Human Endogenous Metabolite體外研究 Linoleic acid contains unsaturated double bonds that are highly vulnerable to free radical attack andoxi

5、dation. If ROS are produced in great quantities, the body can no longer efficiently remove them. In suchinstances, ROS may be released into the extracellular space, causing damage to surrounding cells andtissues. Linoleic acid is a decomposition product of a free fatty acid and has been linked to erythrocytedamage 1.REFERENCES1. Yuan T, et al. Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism. Int J Clin Exp Pathol. 2015 May1;8(5):5044-52.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-