1、精品文獻評價報告學生姓名： *班級 : *學號： *本科專業： *現攻讀專業： *導師：*評價論文題目：Association between low-dose folic acid supplementation and bloodlipids concentrations in male and female subjects with atherosclerosis risk factors.出處：Med Sci Monit. 2013; 19: 733739.設計類型 : DRUG CONTROLLED STUDIES藥物對照研究論文性質：預防1. 選題是否具有科學性與創新性?文章的提

2、出有科學性，有創新性，可行性，與臨床密切相關However, the preventive effect of FA on cardiovascular disease remains unclear.Large-scale clinical trials failed to show a benefit from Hcy-lowering treatment inindividuals with established cardiovascular disease or with history of myocardialinfarction. However, those studies

3、evaluated high-dose FA supplementation assecondary prevention and were not investigating low-dose FA supplementation as感謝下載載精品primary prevention of cardiovascular disease .2. 研究目的是否明確 ?是，明確。The aim of this study was to analyze the association of low-dose folic acidsupplementation with blood lipids c

4、oncentrations in subjects with atherosclerosisrisk factors.3. 設計方案是否作了優選 ? 研究對象是否明確 ?樣本數量是否作了估算 ?類型：藥物對照（自身前后對照），臨床試驗性研究樣本選擇： Initially, FA supplementation was offered to 147 subjects, 23 of whom(15.6%) were excluded in the course of the study due to non-compliance (irregulartaking of FA, stopping i

5、t altogether, or not reporting for the follow-up examinationat the end of the treatment period).未做樣本含量估算。The study enrolled 124 Caucasian individuals (60 M, ages 2039; and 64 F, ages 1939) with atherosclerosis risk factors (family history of premature ischemic stroke, arterial hypertension, dyslipid

6、emia, overweight and obesity, cigarette smoking, and low level of physical activity).樣本選取合適感謝下載載精品4. 診斷標準 / 納入標準 / 排除標準是否明確 ?衡量指標是否恰當 ?所用名詞定義明確，診斷指標，測量方法，結局指標清晰，可靠性高5. 研究或試驗流程是否明確 ?有無質量控制措施？共 5 個表，結果清晰，資料詳盡，內部符合性高6. 統計方法是否正確 ?采用統計方法合理，按男女分層分析，再按不同危險因素分析，控制和調整了混雜因素7. 對該論文的總體感受如何 ？設計清晰，數據清晰，指標明確，有創新，貼近臨床版面清晰In view of our results, it seems that low-dose FA supplementation, used as primaryprevention, has a beneficial effect on blood lipids through decreasingconcentrations of total cholesterol and LDL and increasing concentrations of apoAI.To determine the value of FA in prima