Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEXanomeline-d3Cat.No.:HY-105182S1CASNo.:175615-28-8Synonyms:LY-246708-d3分?式:C??H??D?N?OS分?量:284.44作?靶點:Isotope-LabeledCompounds;mAChR作?通路:Others;GPCR/GProtein;NeuronalSignaling儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Xanomeline-d3(LY-246708-d3)氘代標記的Xanomeline.Xanomeline作為?種有效的選擇性毒蕈堿1型和4型(M1/M4)受體激動劑可增加神經元興奮性。Xanomeline可?于精神分裂癥等神經障礙的研究[1][2]。體外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-216.[2].KreirM,etal.RoleofKv7.2/Kv7.3andM1muscarinicreceptorsintheregulationofneuronalexcitabilityinhiPSC-derivedneurons.EurJPharmacol.2019;858:172474[3].ShekharA,etal.Selectivemuscarinicreceptoragonistxanomelineasanoveltreatmentapproachforschizophrenia.AmJPsychiatry.2008;165(8):1033-1039.[4].AndersenMB,etal.ThemuscarinicM1/M4receptoragonistxanomelineexhibitsantipsychotic-likeactivityinCebusapellamonkeys.Neuropsychopharmacology.2003;28(6):1168-1175.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>