Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemED3/5-HTreceptormodulator-1Cat.No.:HY-10861CASNo.:898532-85-9分?式:C??H??N?O?分?量:391.51作?靶點(diǎn):5-HTReceptor;DopamineReceptor作?通路:GPCR/GProtein;NeuronalSignaling儲存?式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:50mg/mL(127.71mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.5542mL12.7711mL25.5421mL5mM0.5108mL2.5542mL5.1084mL10mM0.2554mL1.2771mL2.5542mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?，-20°C儲存時(shí)，請?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性D3/5-HTreceptormodulator-1(compound5i)?種選擇性多巴胺D3受體和5-HT2A受體拮抗劑，也部分5-HT1A受體激動劑。D3/5-HTreceptormodulator-1對多巴胺D3、5-HT2A和5-HT2A受體的Ki值分別為4.5nM、11.9nM和15.3nM。D3/5-HTreceptormodulator-1對多巴胺D2受體、5-HT2C受體和hERG通道的親和?較低。D3/5-HTreceptormodulator-1具有?典型抗精神疾病特性。IC50&TargetD3Receptor5-HT1AReceptor5-HT2AReceptor5-HT2CReceptor1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE4.5nM(Ki)11.9nM(Ki)15.3nM(Ki)206nM(Ki)D2ReceptorD1ReceptorhERGChannels263nM(Ki)3290nM(Ki)930nM(Ki)REFERENCES[1].ButiniS,etal.DiscoveryofanewclassofpotentialmultifunctionalatypicalantipsychoticagentstargetingdopamineD3andserotonin5-HT1Aand5-HT2Areceptors:design,synthesis,andeffectsonbehavior.JMedChem.2009Jan8;52(1):151-69.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>