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MicrobiologyDepartment

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Microbiology,

HMUDepartment

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Microbiology,

Harbin

Medical

University第二篇

致病性細菌Department

of

Microbiology,

Harbin

Medical

UniversityC■li第ck21t章o

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style微生物學教研室錢鈞教學大綱Department

of

Microbiology,

Harbin

Medical

University掌握內容：白喉棒狀桿菌形態染色、培養 特性致病物質及所致疾病微生物學檢查法及特異性防治原則熟悉內容：白喉棒狀桿菌的免疫性及錫克試驗原 理及結果判定了解內容：棒狀桿菌屬的分類、分布及致病性問題白喉棒狀桿菌的特異性預防白喉棒狀桿菌致病物質及所致疾病Department

of

Microbiology,

Harbin

Medical

University白喉棒狀桿菌（C．dephtheriae）類白喉桿菌（diphtheroidbacilli）假白喉棒狀桿菌結膜干燥桿菌陰道棒狀桿菌痤瘡棒狀桿菌棒狀桿菌屬Corynebacterium白喉棒狀桿菌（C．dephtheriae）類白喉桿菌（diphtheroid

bacilli）Department

of

Microbiology,

Harbin

Medical

UniversityClick

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Master

title

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Master

subtitle

styleDepartment

of

Microbiology,

Harbin

Medical

UniversityDepartment

of

Microbiology,

Harbin

Medical

UniversityDepartment

of

Microbiology,

Harbin

Medical

UniversityDepartment

of

Microbiology,

Harbin

Medical

University白喉毒素（diphtheria

toxin）毒性強、具有高度抗原性的蛋白質由A、B兩個肽鏈經二硫鍵連接組成阻斷宿主細胞蛋白質合成索狀因子（cord

factor）K抗原致病物質白喉毒素（diphtheria

toxin）索狀因子（cord

factor）K抗原Department

of

Microbiology,

Harbin

Medical

UniversityDepartment

of

Microbiology,

Harbin

Medical

University白喉棒狀桿菌（鼻咽腔）飛沫、污染物品鼻咽喉氣管局部細菌和毒素的作用灰白色假膜外毒素入血毒血癥肝腎上腺粘膜水腫及假膜脫落，引起呼吸道阻塞，甚至窒外周神經息死亡。聲嘶心肌心肌炎

內臟出血

腎上腺功

軟腭麻痹能障礙2-7天潛伏期所致疾病：白喉Department

of

Microbiology,

Harbin

Medical

UniversityDepartment

of

Microbiology,

Harbin

Medical

University免疫性抗毒素免疫錫克試驗（Schick

test）原理：毒素和抗毒素的中和試驗Department

of

Microbiology,

Harbin

Medical

University標本假膜邊緣棉拭子取材直接涂片鏡檢美藍、革蘭、奈瑟染色法分離培養呂氏血清斜面毒力試驗豚鼠試驗瓊脂平板毒力試驗微生物學檢查法標本直接涂片鏡檢分離培養毒力試驗Department

of

Microbiology,

Harbin

Medical

University人工自動免疫注射白喉類毒素白喉類毒素、百日咳菌苗、破傷風類毒素的混合制劑（DPT）進行人工自動免疫，效果良好人工被動免疫白喉抗毒素進行緊急預防同時注射白喉類毒素以延長免疫力注射前做皮試，陽性者應采取脫敏注射抗菌治療防治原則人工自動免疫人工被動免疫抗菌治療Department

of

Microbiology,

Harbin

Medical

University小結棒狀桿菌屬