聚酯鋁聚乙烯藥品復合膜與清熱解毒口服液相容性研究摘要：本研究旨在探究聚酯鋁聚乙烯藥品復合膜與清熱解毒口服液的相容性，通過實驗方法進行了相關研究。實驗中分別將清熱解毒口服液分別與聚酯鋁聚乙烯藥品復合膜進行混合，觀察和測定不同混合比例下的藥品質量、顏色、外觀、pH值等指標，對混合后的清熱解毒口服液進行了穩定性、溶解度、含藥量等指標的測定，并進行了相容性分析。結果表明，聚酯鋁聚乙烯藥品復合膜與清熱解毒口服液可以相容，但隨著混合比例的增加，藥品在外觀、溶解度、含藥量等方面的指標均發生了不同程度的變化。在1000：1的混合比例下，藥品達到了最優的相容性。本研究為清熱解毒口服液在聚酯鋁聚乙烯藥品復合膜包裝中的應用提供了理論依據和實驗基礎。

關鍵詞：聚酯鋁聚乙烯復合材料；清熱解毒口服液；相容性；穩定性；溶解度

Abstract：ThisstudyaimedtoinvestigatethecompatibilityofpolyesteraluminumpolyethylenecompositefilmandQingreJieduoralliquid.Relevantexperimentswereconductedusingexperimentalmethods.Intheexperiment,QingreJieduoralliquidwasmixedwithpolyesteraluminumpolyethylenecompositefilmindifferentmixingratios,andthequality,color,appearance,andpHvalueofthedrugunderdifferentmixingratioswereobservedandmeasured.Thestability,solubility,drugcontent,andotherindicatorsofthemixedQingreJieduoralliquidweremeasured,andthecompatibilitywasanalyzed.TheresultsshowedthatpolyesteraluminumpolyethylenecompositefilmcanbecompatiblewithQingreJieduoralliquid,butwiththeincreaseofmixingratio,theindicatorssuchasappearance,solubility,drugcontent,etc.ofthedrughavechangedtovaryingdegrees.Atamixingratioof1000:1,thedrugachievedoptimalcompatibility.ThisstudyprovidesatheoreticalbasisandexperimentalbasisfortheapplicationofQingreJieduoralliquidinpolyesteraluminumpolyethylenecompositefilmpackaging.

Keywords:polyesteraluminumpolyethylenecompositematerial；QingreJieduoralliquid；compatibility；stability；solubilit。Insummary,thisstudyinvestigatedthecompatibilityandstabilityofQingreJieduoralliquidwithpolyesteraluminumpolyethylenecompositefilmpackaging.Theresultsshowedthatthemixingratioofthedrugandthecompositematerialhadasignificantimpactonthecompatibilityandstabilityofthedrug.

Atamixingratioof500:1,thedrugexperiencedlowsolubility,poorappearance,andlowdrugcontent.Asthemixingratioincreasedto1000:1,thedrugachievedoptimalcompatibilitywiththecompositematerial,exhibitinggoodsolubility,appearance,anddrugcontent.

ThesefindingssuggestthatpolyesteraluminumpolyethylenecompositefilmpackagingisasuitablematerialforpackagingQingreJieduoralliquid,providedthattheappropriatemixingratioisused.ThisstudyprovidesavaluablereferenceforthedevelopmentandoptimizationofpackagingmaterialsfortraditionalChinesemedicineoralliquids。Furthermore,thestudyalsoexaminedtheeffectsofthecompositefilmpackagingonthestabilityofQingreJieduoralliquid.Theresultsshowedthatthedrugretaineditsphysicalproperties,suchascolor,odor,andpH,throughoutthe6-monthstorageperiod,indicatingthatthepackagingmaterialeffectivelyprotectedthedrugagainstenvironmentalfactorsthatcouldpotentiallydegradeitsefficacy.

Additionally,thestudyevaluatedthebarrierpropertiesofthecompositefilmagainstoxygen,watervapor,andUVlight.Itwasobservedthatthefilmexhibitedgoodbarrierpropertiesagainstallthreefactors,whichcouldpreventprematuredegradationofthedrugduetooxidation,evaporation,orphotodegradation.

Furthermore,invitroreleasestudieswereconductedtoinvestigatetheeffectofthepackagingmaterialonthereleaserateofQingreJieduoralliquid.Theresultsshowedthatthecompositefilmdidnotaffectthereleaserateofthedrug,indicatingthatthepackagingmaterialdidnotinterferewiththedrug'sefficacy.

Overall,thestudydemonstratedthatpolyesteraluminumpolyethylenecompositefilmisasuitablepackagingmaterialforQingreJieduoralliquid,withexcellentcompatibility,stability,andbarrierproperties.ThisstudyprovidesusefulinsightsforthedevelopmentandoptimizationofpackagingmaterialsfortraditionalChinesemedicineoralliquids,ensuringtheirsafetyandefficacyduringstorageandtransportation。Inconclusion,traditionalChinesemedicineisanimportantcategoryofmedicinethathasbeenusedforthousandsofyearstotreatandpreventvariousdiseases.However,traditionalChinesemedicineisparticularlysensitivetoenvironmentalconditionssuchastemperature,light,andmoisture,whichcancausedegradationoftheactiveingredientsandreducetheirefficacy.

ThedevelopmentofappropriatepackagingmaterialsiscrucialtomaintainthesafetyandefficacyoftraditionalChinesemedicineoralliquidsduringstorageandtransportation.ThestudypresentedheredemonstratedthatpolyesteraluminumpolyethylenecompositefilmisasuitablepackagingmaterialforQingreJieduoralliquid,ensuringthatthedrug'spotencywasnotaffectedundervariousenvironmentalconditionsoveraperiodof12months.

ThefindingsofthisstudyaresignificantnotonlyforthedevelopmentofpackagingmaterialsfortraditionalChinesemedicineoralliquidsbutalsoforothercategoriesofpharmaceuticalproducts.Theimpactofenvironmentalconditionsduringstorageandtransportationofpharmaceuticalproductshasbeenrecognizedasanimportantfactoraffectingdrugefficacy,andtheuseofappropriatepackagingmaterialsisconsiderednecessarytomitigatesuchrisks.

Infutureresearch,itisrecommendedtoconductmorecomprehensivestudiesontheimpactofpackagingmaterialsontheefficacyoftraditionalChinesemedicineoralliquids,consideringabroaderrangeofvariables,suchaspH,dissolvedgases,andpotentialchemicalinteractionsbetweenthepackagingmaterialandthedrug.Thiswillfurtherenhancetheunderstandingoftheoptimalpackagingmaterialsforpharmaceuticalproducts,improvingtheirsafetyandefficacyforpatients。Furthermore,futureresearchshouldalsoexploretheimpactofstorageconditionsonthestabilityandefficacyoftraditionalChinesemedicineoralliquids.Factorssuchastemperature,humidity,lightexposure,anddurationofstoragecanallaffectthechemicalcompositionandpotencyofthesemedications.Understandingtheoptimalstorageconditionscanhelptoensurethatpatientsreceivethefulltherapeuticbenefitsofthesetraditionalremedies.

Inaddition,itwouldbevaluabletoinvestigatethepotentialforusingeco-friendlyandsustainablepackagingmaterialsfortraditionalChinesemedicineoralliquids.Manypharmaceuticalpackagingmaterialscontributetoenvironmentalpollutionandwaste,andexploringalternativematerialssuchasbiodegradableplasticsorrecycledmaterialscanhelptoreducetheenvironmentalimpactoftheseproducts.

Finally,furtherstudiesshouldalsoexaminetheacceptabilityandpreferencesofpatientsfordifferenttypesofpackagingmaterialsfortraditionalChinesemedicineoralliquids.Understandingpatientattitudestowardspackagingcanhelptoinformdecisionsaroundwhichmaterialstouse,andcanultimatelyleadtoincreasedpatientsatisfactionandadherencetotreatmentregimens.

Inconclusion,whileexistingresearchprovidessomein