1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDimethylfraxetinCat. No.: HY-N0085CAS No.: 6035-49-0Synonyms: 6,7,8-Trimethoxycoumarin; Fraxetin dimethyl ether分式: CHO分量: 236.22作靶點(diǎn): Carbonic Anhydrase作通路: Metabolic Enzyme/Protease儲(chǔ)存式: Powder -20C 3 years4C 2 yearsIn solvent -8

2、0C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 125 mg/mL (529.17 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 4.2333 mL 21.1667 mL 42.3334 mL5 mM 0.8467 mL 4.2333 mL 8.4667 mL10 mM 0.4233 mL 2.1167 mL 4.2333 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGICAL ACTI

3、VITY物活性 Dimethylfraxetin種 Carbonic anhydrase 抑制劑，其 Ki 值為 0.0097 M。IC50 & Target Ki: 0.0097 M (Carbonic anhydrase) 1體外研究At CA I there is one stand out compound being Dimethylfraxetin (compound 17), a nanomolar CA I inhibitor.This trimethoxy coumarin is the most potent of any of the NP coumarins acros

4、s the six CA isozymes of the1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEpresent study 1.PROTOCOLKinase Assay 1 Inhibitor (including Dimethylfraxetin) and enzyme solutions are preincubated together for 6 h at roomtemperature prior to assay, in order to allow for the formation of the enzyme-inhib

5、itor complex 1.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Davis RA, et al. Natural product coumarins that inhibit human carbonic anhydrases. Bioorg Med Chem. 2013 Mar 15;21(6):1539-43.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5