1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDiphenmanil methylsulfateCat. No.: HY-16171CAS No.: 62-97-5Synonyms: Diphemanil mesylate分式: CHNOS分量: 389.51作靶點: mAChR作通路: GPCR/G Protein; Neuronal Signaling儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解

2、性數據體外實驗 : 16.67 mg/mL (42.80 mM; Need ultrasonic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.5673 mL 12.8366 mL 25.6733 mL5 mM 0.5135 mL 2.5673 mL 5.1347 mL10 mM 0.2567 mL 1.2837 mL 2.5673 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Diphemanil硫酸甲酯能結合毒蕈堿型酰膽堿受體進降低胃酸，唾

3、液和汗液的分泌排泄。REFERENCES1. Kng M, Diamond L. Effect of inhaled diphemanil methylsulfate, a parasympatholytic agent, on histamine induced bronchoconstriction in1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEasymptomatic asthmatics. Ann Allergy. 1984 Jan;52(1):22-5.2. Vidal AM, Rey E, Pons G et al. Phar

4、macokinetics of diphemanil methylsulphate in healthy subjects. Eur J Clin Pharmacol.1992;42(6):689-91.3. Vidal AM, Chron G, Rey E et al. Pharmacokinetics of diphemanil methylsulphate in infants. Eur J Clin Pharmacol. 1993;45(1):89-91.4. Chron G, Vidal AM, Rey E et al. Pharmacokinetics of diphemanil

5、methylsulfate in infants. Arch Pediatr. 1994 Jan;1(1):33-7.5. Adamantidis M, Dumotier B, Caron J, Dupuis B. Electrophysiologic effects and arrhythmogenic potential of diphemanil methylsulfate onrabbit purkinje fibers. Correlations with clinical observations of QT prolongation in pediatrics. Arch Mal Coeur Vaiss. 1998 Dec;91(12):1487-94.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 0