1、自噬的生理學與病理生理學作用自噬的生理學與病理生理學作用physiological and pathphysiological roles of autophagyprotein degradation systemubiquitin-proteasomeautophagylysosome1% 99%5 hours198019622004 ?nobel prize discoveryhalf-lifepercentagee1(泛素活化酶)e2(泛素結合酶)e3(泛素-蛋白連接酶)比利時科學家德比利時科學家德迪夫迪夫衰老的線粒體衰老的線粒體衰老的過氧化物酶體衰老的過氧化物酶體function o

2、f autophagy a.housekeeping mechanism involved in cytoplasmic homeostasisb. involved in certain tissue-specific functionscell death immune response development and agingc. autophagy in disease cancerneurodegenerative diseasesparkinson, huntington, alzheimermuscular diseaseshuman cardian skeletal myop

3、athic danon disease autophagy (self-eating)apoptosis (self-killing) not good or bad but good and badautophagy巨型自噬(macroautophagy) 微型自噬(microautophagy) 分子伴侶介導的自噬(chaperon-mediated autophagy) 細胞自噬的類型細胞自噬的類型細胞自噬的類型細胞自噬的類型細胞自噬的機制細胞自噬的機制the machinery of autophagy molecular regulation mechanism of autopha

4、gy pi3k-akt-mtor lkb1-ampk-mtor beclin1-bcl-2 p53 other mechanismsmolecules and their functions in autophagyidentification of atg genes and their functions.mtor regulationof autophagycrosstalk between er stress, apoptosis and autophagy pathways細胞自噬的類型細胞自噬的類型mitophagy : mitochondriapexophagy: peroxisomes,reticulophagy: endoplasmic reticulumorganelle selective modes selective autophagyp