Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEEvogliptin-d9Cat.No.:HY-117985SSynonyms:DA-1229-d9分?式:C??H??D?F?N?O?分?量:410.48作?靶點:Isotope-LabeledCompounds;Autophagy;DipeptidylPeptidase作?通路:Others;Autophagy;MetabolicEnzyme/Protease儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Evogliptin-d9(DA-1229-d9)氘代標記的Evogliptin.Evogliptin(DA-1229)?種?服有效的DPP4抑制劑，在??模型中具有顯著?持久的降糖效果。Evogliptin還可通過誘導?噬來抑制肝細胞的炎癥和纖維化信號的產?。Evogliptin可?于2型糖尿病、?質疏松癥，腎功能損害以及慢性肝臟炎癥的研究。體外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-216.[2].YoonH,etal.EffectsoftheAntidiabeticDrugsEvogliptinandSitagliptinontheImmuneFunctionofCD26/DPP4inTh1Cells.BiomolTher(Seoul).2021Mar1;29(2):154-165.[3].SeoHY,etal.EvogliptinDirectlyInhibitsInflammatoryandFibroticSignalinginIsolatedLiverCells.InternationalJournalofMolecularSciences,2022,23(19):11636.[4].KimTH,etal.Hepaticroleinanearlyglucose-loweringeffectbyanoveldipeptidylpeptidase4inhibitor,evogliptin,inarodentmodeloftype2diabetes.EurJPharmacol.2016Jan15;771:65-76.[5].TanX,etal.Evogliptin:anewdipeptidylpeptidaseinhibitorforthetreatmentoftype2diabetes.ExpertOpinPharmacother.2016Jun;17(9):1285-93.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;