Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEK34chydrochlorideCat.No.:HY-150124ACASNo.:2986315-25-5分?式:C??H??ClN?O?分?量:483.99作?靶點(diǎn):Integrin;Apoptosis作?通路:Cytoskeleton;Apoptosis儲(chǔ)存?式:4°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:125mg/mL(258.27mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.0662mL10.3308mL20.6616mL5mM0.4132mL2.0662mL4.1323mL10mM0.2066mL1.0331mL2.0662mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性K34chydrochloride?種有效的、選擇性α5β1integrin拮抗劑。K34chydrochloride抑制α5β1integrin可減輕化療誘導(dǎo)的細(xì)胞過早衰?，并促進(jìn)細(xì)胞凋亡(Apoptosis)。K34chydrochloride可?于膠質(zhì)母細(xì)胞瘤研究[1]。體外研究K34c(20μM;24or48h)significantlyinducesU87MGcellsapoptosisincombinationwith1μMEllipticine(HY-15753)[1].1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEK34c(20μM;48h)significantlydecreasesTemozolomide(HY-17364)-inducedsenescenceincellstransfectedwithcontrolnontargetingsiRNAwithoutaffectingsignificantlytheresidualsenescenceofcellstransfectedwithsiRNAspecificforp53[1].REFERENCES[1].MartinkovaE,etal.alpha5beta1integrinantagonistsreducechemotherapy-inducedprematuresenescenceandfacilitateapoptosisinhumanglioblastomacells.IntJCancer.2010Sep1;127(5):1240-8.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955