Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEGaboxadolhydrochloride(Standard)Cat.No.:HY-10233RCASNo.:85118-33-8Synonyms:Lu02-030hydrochloride(Standard);THIPhydrochloride(Standard)分?式:C?H?ClN?O?分?量:176.6作?靶點:GABAReceptor作?通路:MembraneTransporter/IonChannel;NeuronalSignaling儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Gaboxadol(hydrochloride)(Standard)Gaboxadol(hydrochloride)的分析標準品。本產品?于研究及分析應?。Gaboxadolhydrochloride(Lu02-030hydrochloride)?種強效有?的GABAAreceptor的激動劑和GABACreceptors受體拮抗劑(IC50=25μM)。Gaboxadolhydrochloride在亞α1β2γ2顯?部分激動劑功效，ED50值為143μM，在α5亞顯?出?個完整的受體激動劑功效(ED50=28-129μM)以及在α4β3δ亞也有激動作?(ED50=6μM)。Gaboxadolhydrochloride?種?阿?類試劑。IC50&TargetGABAAreceptor;GABACreceptor[1]REFERENCES[1].JohnstonGA,etal.NeurochemicalsfortheinvestigationofGABA(C)receptors.NeurochemRes.2010Dec;35(12):1970-7.[2].CogramP,etal.GaboxadolNormalizesBehavioralAbnormalitiesinaMouseModelofFragileXSyndrome.FrontBehavNeurosci.2019Jun25;13:141.[3].LarsenM,etal.IntestinalgaboxadolabsorptionviaPAT1(SLC36A1):modifiedabsorptioninvivofollowingco-administrationofL-tryptophan.BrJPharmacol.2009Aug;157(8):1380-9.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021