TriacylglycerolSynthesis1306劉澤萱文眸俞婕曹爍施舒鵬余夢(mèng)左婉蕓楊暉豪嚴(yán)予晗張揚(yáng)易1AboutTAG2contentBasicstructureofTAGSynthesisofTAGFatesofTAGinliverandadiposetissue3BasicstructureofTAGnegativechargeneutralfat4BasicstructureofTAG5Thefattyacidoncarbon1istypicallysaturated,thatoncarbon2istypicallyunsaturated,andthatoncarbon3canbeeither.unsaturatedfattyacid(s)decrease(s)theTmofthelipidBasicstructureofTAG6BasicstructureofTAGatroomtemperature：solidfatliquidoil7BasicstructureofTAG8contentBasicstructureofTAGSynthesisofTAGFatesofTAGinliverandadiposetissue9SynthesisofTAG10SynthesisofTAGLIVER11SynthesisofTAG12SynthesisofTAGLiverAdiposecellsLiver13SynthesisofTAG14SynthesisofTAGfreefattyacidactivedformActivationofafreefattyacid脂肪酸必須被活化（連接上CoA）才能參與代謝過程，對(duì)于TAG的合成，由脂酰CoA合酶或者叫硫激酶（這是種同工酶）催化。15SynthesisofTAGTowsteps：Furtherhydrolysisofhigh-energyphosphatebondinPPireleasesmuchmoreenergyforfattyacyl-CoAsynthesis.16SynthesisofTAG17SynthesisofTAGAnotherpathwayforTAGsynthesis(Inintestinalmucosacells)Enzyme:單酰甘油脂酰CoA轉(zhuǎn)移酶

（monoacylglycerolaceyltransferase）

二酰甘油脂酰CoA轉(zhuǎn)移酶(diacylglycerolaceyltransferase)MAG:單酰甘油(monoacylglycerol)18SynthesisofTAGCoA+RCOOHRCOCoAacylCoAsynthetaseATPAMPPPi

AcylCoAtransferase

CoAR2COCoAR3COCoACoA

AcylCoAtransferase19contentBasicstructureofTAGSynthesisofTAGFatesofTAGinliverandadiposetissue20FatesofTAGinliverandadiposetissueInWAT(脂肪),itservesas“depotfat,”readyformobilizationwhenthebodyrequiresitforfuel21FatesofTAGinliverandadiposetissueAdipocytesMusclefibre(lipiddroplet)22FatesofTAGinliverandadiposetissueInhealthyliver:littlebestoredBeingpackagedwithotherlipidsandapolipoproteintoformlipoproteinparticlescalledvery-low-densitylipoproteins(VLDL)23FatesofTAGinliverandadiposetissueIntroduction：VLDLisoneofthefivemajorgroupsoflipoproteins(chylomicrons,VLDL,

LDL，intermediate-densitylipoprotein,

high-densitylipoprotein).Itis

madebythe

liverandassembledinthe

liver

from

triglycerides,

cholesterol,and

apolipoproteins.VLDLparticleshaveadiameterof30-80

nm.and,

thatenablefatsand

cholesterol

tomovewithinthewater-basedsolutionofthebloodstream.Function：VLDLtransports

endogenous