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xx年xx月xx日英文醫學課件資料：osteoporosisCATALOGUE目錄IntroductiontoOsteoporosisPathogenesisandPathologyofOsteoporosisClinicalManifestationandDiagnosisofOsteoporosisCATALOGUE目錄TreatmentandProphylaxisofOsteoporosisCaseStudies01IntroductiontoOsteoporosisOsteoporosisisacommonskeletaldiseasecharacterizedbylowbonemassandmicro-architecturalchangesinbonetissue,leadingtoenhancedbonefragilityandriskoffracture.Itisachronic,progressive,anddebilitatingconditionthatprimarilyaffectspostmenopausalwomenandelderlymen.DefinitionofOsteoporosisTypeIosteoporosisTypeIIosteoporosisClassificationofOsteoporosisGeneticf…Genderan…Nutrition…Lifestyle…CausesofOsteoporosis0102030402PathogenesisandPathologyofOsteoporosisNon-geneticfactorsTheseincludeage,gender,race,menopause,lowweight,andalackofexercise.要點一要點二GeneticfactorsTheseincludefamilyhistory,ethnicity,andspecificgenemutationsthatcanincreasetheriskofdevelopingosteoporosis.PathogenesisofOsteoporosisThisisthemostcommonfeatureofosteoporosisandiscausedbyanimbalanceinboneresorptionandboneformation.PathologyofOsteoporosisThisiscausedbythelossofbonemassandmicroarchitecturalchanges.LossofbonemassMicroarchitectura…Decreasedbonest…Dual-energyX-ra…ImagingFeaturesofOsteoporosisQuantitativecom…Magneticresonan…03ClinicalManifestationandDiagnosisofOsteoporosisClinicalManifestationofOsteoporosisPainBonepaincausedbymicro-fracturesandstressfractures.Spinalcurvature,kyphosis,scoliosis,andotherbonedeformities.Easytosustainfractures,evenwithoutobvioustrauma.DeformityFragilityBMD(BoneMineralDen…Thestandardfordiagnosisandevaluationofosteoporosis.T-scoreThedifferencebetweenthepatient'sBMDandthepeakbonemassofhealthyyoungadults.FRAX(FractureRiskA…AtoolforassessingtheriskoffracturebasedonclinicalriskfactorsandBMD.DiagnosticCriteriaforOsteoporosisOsteoporosiscausedbyvariousdiseasesordrugs.DifferentialDiagnosisofOsteoporosisAbonediseasecharacterizedbyfocalboneremodeling.HereditarybonediseasewithlowBMDandmultiplefractures.Secondaryosteopo…Paget'sdiseaseOsteogenesisimpe…04TreatmentandProphylaxisofOsteoporosisPharmacologicalTherapyforOsteoporosisincludingbisphosphonates,denosumab,andselectiveestrogenreceptormodulators,whichcanreduceboneturnoverandpreventboneloss.Antiresorptiveagentsincludingteriparatideandabaloparatide,whichcanstimulateboneformationandincreasebonemass.AnabolicagentsCalciumandv…Non-pharmacologicalTherapyforOsteoporosisExercisesmokingisariskfactorforosteoporosisandcanaccelerateboneloss.Smokingcessa…excessivealcoholconsumptioncanhaveadverseeffectsonbonehealth.Limitalcohol…Identifyindivid…ProphylaxisofOsteoporosisModifyriskfact…reducemodifiableriskfactorssuchassmoking,alcoholconsumption,andlowcalciumintake.Screening05CaseStudiesCaseStudy1:OsteoporosisinPost-menopausalWomenpost-menopausalwomenwithlowtraumafracturesDxlowBMDandserummarkersofboneturnoverLabtestsbonelossandmicro-architecturaldamageImagingbone-targetedtherapytoreducefractureriskRx01menwithlowtraumafracturesand/orBMDT-score<-2.5athiporspineDxCaseStudy2:OsteoporosisinMen02serummarkersofboneturnoverandurinarymarkersofboneresorptionLabtests03bonelossandmicro-architecturaldamageonHRpQCTandtrabecularbonescoreImaging04bone-targetedtherapytoreducefractureriskRxDxchildren/adolescentswithfragilityfracturesand/orheightloss>2cminpastyearLabtestsserummarkersofboneturnoverandurinarymarkersofboneresorptionImagingtrabecularbonepatternanalysis

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