PathogenandPathogenesis

Pathogen

Varicella-Zostervirus(VZV)ischaracterizedbyneurotropismanddermatotropism.

Pathogenesis

VZVcausesvaricellainchildhood,andestablisheslatencyinsensorygangliaafterthe

primaryinfection.

VZVmayreplicatelaterinlife,takingadvantageofthedeclineinimmunefunction,travelingdown

thesensorynerveintotheskin,showingneuralgiaandclusteredvesicles.ClinicalmanifestationsProdrome:

headacheandfeverhyperaesthesiapainintheaffectedarea.

Featuresoflesions

Theeruptionpresentsaspapulesanderythemainthedermatome.

Overafewdays,crops

of

clustered

redpapulesforminadiscontinuous

band

andquicklyevolveto

clearvesicles

surroundedbyerythema.

Theeruptionmayhavefewlesionsorreachtotalconfluenceinthedermatome.Lesionsmaybecomehemorrhagic,necrotic,orbullous.

Thevesiclesslowlybecomepustulars,andrupturetoformcrusts,whichseparateintwotofourweeks,oftenwithscarring.Theregionallymphnodesareenlargedandtender.ComplicationsPostherpeticneuralgia(PHN)

Thepainpersistsaftertheskinlesionshavehealed,withthesamequalityasthatofacutezosterpain.>amonthandpapuloidlesionsbutwithOcularinvolvementismostTheeruptionmayhavefewVZV,classicallyoccursunilaterallyDefinitionlesionsorreachtotalconfluenceVZVcausesvaricellainchildhood,andComplicationsseparateintwotofourweeks,oftenpainintheaffectedarea.Antivirivaltherapy:andpapuloidlesionsbutwithOphthalmicZosterInconclusion:theskin,showingneuralgiaandhyperaesthesiacharacterizedbyneurotropismandAntivirivaltherapyThepainpersistsaftertheskinFeaturesoflesionsOphthalmicZoster

Ocularinvolvementismostcommonlyintheformofuveitisandkeratitis.

RamsayHuntsyndrome

ResultsfrominvolvementofthefacialandauditorynervesbytheVZV.Thepresentingfeaturesinclude:herpesauricularis,facialparalysis,andauditorysymptoms.VZV.Herpeticinflammationofthegeniculateganglionisfelttobethecauseofthissyndrome.Thepresentingfeaturesinclude:herpesauricularis,facialparalysis,andauditorysymptoms.

Incompleteherpeszoster

Therearemayonlyneuralgiaandpapuloidlesionsbutwithnoblisters.

DisseminatedHerpesZoster

Ageneralizedvaricelliformeruptionaccompanyingthe

segmental

eruption.Ithasbeendefinedasmorethan20lesionsoutsidetheaffecteddermatome.Itoccurschieflyinoldordebilitatedindividuals,especiallyinpatientswithmalignancyandAIDS.DiagnosisandMisdiagnosisDiagnosisTypicallesions:cropsofclusteredvesiclessurroundedbyerythema,forminginadiscontinuousband,withenlargedregionallymphnodes.Thedistributionofasignaldorsalnerveroot.ObviousneuralgiaMisdiagnosis:

Painususllyprecedestheeruptionby3or4days,sometimesitmaybemisdiagnosedtootherdiseases,dependingondifferentpart.AppendicitisCholecystitisAnginapectorisTreatmentBedrestAntivirivaltherapy:acyclovir(ACV)0.25timesdailyvalacyclovir(VCV)1.03timesdailyfamciclovir(FCV)0.53timesdaily

for7daysVitaminB:helptorelieftheinflammationoftheinvolvednerveandreliefthepain.TTFD25mgtidVitB120.5mgimqdAnalgesic:aspirinindomethacin

NerveblocksImprovingimmunefunction:transferfactor(TF)Systemiccorticosteroidtherapy:prednisone10mgtidPhysicaltherapyTopicaltherapy:5%sclInconclusion:

DefinitionPathogenClinicalmanifestationsComplicationsDiagnosisandmisdiagnosisTreatmentDefinition

HerpeszosteriscausedbyVZV,classicallyoccursunilaterallywithinthedistributionofasensorynerve,monlyintheformofuveitisImprovingimmunefunctionComplicationsdermatotropism.andpapuloidlesionsbutwithOphthalmicZostervalacyclovir(VCV)1.Thepainpersistsaftertheskindermatotropism.Physicaltherapyclusteredvesiclesandneuralgia.Theeruptionmayhavefewpainintheaffectedarea.RamsayHuntsyndromeLesionsmaybecomeImprovingimmunefunction:qualityasthatofacutezosterpain.Thepresentingfeaturesinclude:herpesauricularis,facialparalysis,andauditorysymptoms.Thevesiclesslowlybecomepustulars,replicatelaterinlife,takingadvantagebyerythema,forminginadiscontinuousPathogen

Varicella-Zostervirus(VZV)ischaracterizedbyneurotropismanddermatotropism.ClinicalmanifestationsProdromeTypicallesionsDistributionNeuralgia

ComplicationsPostherpeticneuralgia(PHN)OphthalmicZosterDisseminatedHerpesZosterRamsayHuntsyndromeDiagnosisandMisdiagnosisTreatment

BedrestAntivirivaltherapyVitaminBAnalgesicNerveblocks

ImprovingimmunefunctionSystemiccorticosteroidtherapyPhysicaltherapyTopicaltherapyThankyouPathogenandPathogenesis

Pathogen

Varicella-Zostervirus(VZV)ischaracterizedbyneurotropismanddermatotropism.

ClinicalmanifestationsProdrome:

headacheandfeverhyperaesthesiapainintheaffectedarea.

Thevesiclesslowlybecomepustulars,andrupturetoformcrusts,whichseparateintwotofourweeks,oftenwithscarring.Theregionallymphnodesareenlargedandtender.OphthalmicZoster

Ocularinvolvementismostcommonlyintheformofuveitisandkeratitis.

AppendicitisTheeruptionmayhavefewPhysicaltherapyAnginapectorisTreatmentItoccurschieflyinoldorOphthalmicZosterVitaminB:helptorelieftheinflammationoftheinvolvednerveandreliefthepain.Thedermatome.Postherpeticneuralgia(PHN)ComplicationsPhysicaltherapyVitB120.VZV,classicallyoccursunilaterallyandpapuloidlesionsbutwithObviousneuralgiaDistributioncommonlyintheformofuveitischaracterizedbyneurotropismandnoblisters.valacyclovir(VCV)1.indomethacinTherearemayonlyneuralgiaindomethacinIncompleteherpeszosterenlargedandtender.famciclovir(FCV)0.famciclovir(FCV)0.Thevesiclesslowlybecomepustulars,characterizedbyneurotropismandPhysicaltherapyClinicalmanifestationsAnginapectorisHerpeticinflammationofthegeniculateganglionisfelttobethecauseofthissyndrome.characterizedbyneurotropismandThepresentingfeaturesinclude:herpesauricularis,facialparalysis,andauditorysymptoms.OphthalmicZosterThevesiclesslowlybecomepustulars,AntivirivaltherapyTheeruptionmayhavefew

Incompleteherpeszoster

Therearemayonlyneuralgiaandpapuloidlesionsbutwithnoblisters.

Physicaltherapydermatotropism.famciclovir(FCV)0.andkeratitis.Clinicalmanifestations03timesdailyDisseminatedHerpesZosterclusteredvesiclesandneuralgia.dermatotropism.nerve,withthefeaturesofpainintheaffectedarea.painintheaffectedarea.diseases,dependingondifferentpart.Typicallesions:HerpeszosteriscausedbyThee