Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemETRPV4agonist-1freebaseCat.No.:HY-114400CASNo.:2314467-59-7分?式:C??H??F?N?O?分?量:448.46作?靶點:TRPChannel作?通路:MembraneTransporter/IonChannel;NeuronalSignaling儲存?式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性數據體外實驗DMSO:83.33mg/mL(185.81mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.2299mL11.1493mL22.2985mL5mM0.4460mL2.2299mL4.4597mL10mM0.2230mL1.1149mL2.2299mL請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。體內實驗請根據您的實驗動物和給藥?式選擇適當的溶解?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結果的可靠性，澄的儲備液可以根據儲存條件，適當保存；體內實驗的?作液，建議您現?現配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現沉淀、析出現象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(4.64mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性TRPV4agonist-1freebase?種瞬時受體電位?草酸亞型4(TRPV4)激動劑，在hTRPV4Ca2+實驗中EC50為60nM[1]。IC50&TargetEC50:60nM(hTRPV4hTRPV4Ca2+)[1]體外研究TRPV4agonist-1(Compound36)exhibitssignificantlyincreasedpotency(ECmax:20nMintheSOX9reporterassay).TRPV4agonist-1isinactiveagainstTRPV1channels[1].REFERENCES[1].AtobeM,etal.DiscoveryofNovelTransientReceptorPotentialVanilloid4(TRPV4)AgonistsasRegulatorsofChondrogenicDifferentiation:IdentificationofQuinazolin-4(3H)-onesandinVivoStudiesonaSurgicallyInducedRatModelofOsteoarthritis.JMcePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-589