Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemELRE1Cat.No.:HY-100524CASNo.:1252362-53-0分?式:C??H??ClN?S分?量:280.78作?靶點:AdenylateCyclase作?通路:GPCR/GProtein儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數據體外實驗DMSO:125mg/mL(445.19mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM3.5615mL17.8075mL35.6151mL5mM0.7123mL3.5615mL7.1230mL10mM0.3562mL1.7808mL3.5615mL請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。體內實驗請根據您的實驗動物和給藥?式選擇適當的溶解?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結果的可靠性，澄的儲備液可以根據儲存條件，適當保存；體內實驗的?作液，建議您現?現配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現沉淀、析出現象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>90%(20%SBE-β-CDinsaline)Solubility:≥2.08mg/mL(7.41mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE2.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.08mg/mL(7.41mM);ClearsolutionBIOLOGICALACTIVITY?物活性LRE1可溶性腺苷酸環化酶的特異性和變構抑制劑。IC50&TargetAdenylylcyclase[1]體外研究LRE1bindstothebicarbonateactivatorbindingsiteandinhibitssolubleadenylylcyclase(sAC)viaauniqueallostericmechanism[1].LRE1preventssAC-dependentprocessesincellularandphysiologicalsystemsandfacilitatesexplorationofthetherapeuticpotentialofsACinhibition[1].LRE1(0.5-100μM,60minutes)inhibitsspermandmitochondrialfunctionsofsAC[1].WesternBlotAnalysis[1]CellLine:MousecaudaspermConcentration:0.5-100μMIncubationTime:60minutesResult:LRE1inhibitssACdependentspermcapacitation[1].戶使?本產品發表的科研?獻?FrontCellDevBiol.2021Nov17;9:772254.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].Ramos-EspirituL,etal.DiscoveryofLRE1asaspecificandallostericinhibitorofsolubleadenylylcyclase.NatChemBiol.2016Oct;12(10):838-44.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400