1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEGlycolic acidCat. No.: HY-W015967CAS No.: 79-14-1分式: CHO分量: 76.05作靶點(diǎn): Endogenous Metabolite; Tyrosinase作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 100 mg/m

2、L (1314.92 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 13.1492 mL 65.7462 mL 131.4924 mL5 mM 2.6298 mL 13.1492 mL 26.2985 mL10 mM 1.3149 mL 6.5746 mL 13.1492 mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內(nèi)實(shí)驗(yàn)請根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥式選擇適當(dāng)?shù)娜芙獍福渲魄罢埾扰渲瞥吻宓膬湟海僖来翁砑又?/p>

3、溶劑(為保證實(shí)驗(yàn)結(jié)果的可靠性，體內(nèi)實(shí)驗(yàn)的作液，建議您現(xiàn)現(xiàn)配，當(dāng)天使；澄清的儲備液可以根據(jù)儲存條件，適當(dāng)保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.5 mg/mL (32.87 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 2.5 mg/mL (32.87 mM); Clear solution3. 請依序添加每種溶劑： 10%

4、DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESolubility: 2.5 mg/mL (32.87 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Glycolic acid酪氨酸酶 (tyrosinase) 的抑制劑，能抑制素的形成，從減淡膚的顏。IC50 & Target Human Endogenous Metabolite體外研究 Different concentrations of Glycolic acid (GA) or LA (300 and 500

5、mg/mL) are tested on the growth of mouseand human melanoma cells. Both types of cells grow well, even in the presence of 300 mg/mL of eachchemical for 5 days. However, 500 mg/mL Glycolic acid inhibits the cell growth of mouse melanoma cells(41%) and humanmelanoma cells (27%), and 500 mg/mL of LA inh

6、ibits the growth of mouse melanoma cells(36%) 1.PROTOCOLCell Assay 1 HM3KO pigmented human melanoma cells and B16 mouse melanoma cells are cultured in Dulbeccosmodified Eagles medium supplemented with 10%fetal calf serum and appropriate amounts of antibiotics andfungizone were dissolved at a concent

7、ration of 100mg/mL in distilled water. These chemicals (e.g., GlycolicAcid ) are added to the cell cultures at final concentrations of 300 or 500 mg/mL every 2 days for 5 days 1.MCE has not independently confirmed the accuracy of these methods. They are for reference only.REFERENCES1. Usuki A, et al. The inhibitory effect of glycolic acid and lactic acid on melanin synthesis in melanoma cells. Exp Dermatol. 2003;12 Suppl2:43-50.McePdfHeightCaution: Product has not been fully validated for medical applications.For res