Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemELamotrigine-13C7,15NCat.No.:HY-B0495S8Synonyms:LTG-13C7,15N;BW430C-13C7,15N分?式:C???C?H?Cl?N???N分?量:264.03作?靶點:Isotope-LabeledCompounds;Autophagy;SodiumChannel作?通路:Others;Autophagy;MembraneTransporter/IonChannel儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Lamotrigine-13C7,15N(LTG-13C7,15N)13C和15N標記的Lamotrigine.Lamotrigine(BW430C)?種有效的，具有?服活性的抗驚厥或抗癲癇試劑(anticonvulsantagent)。Lamotrigine選擇性地阻斷電壓門控鈉離?通道(Na+channels)，穩定突觸前神經元膜，抑制?氨酸釋放。Lamotrigine可?于癲癇、局灶性癲癇等的研究。體外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-216.[2].MJLeach,etal.Pharmacologicalstudiesonlamotrigine,anovelpotentialantiepilepticdrug:II.Neurochemicalstudiesonthemechanismofaction.Epilepsia.Sep-Oct1986;27(5):490-7.[3].DamiankaPGetova,etal.Astudyoftheeffectsoflamotrigineonmiceusingtwoconvulsivetests.FoliaMed(Plovdiv).Apr-Jun2011;53(2):57-62.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792a