Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEEmricasan(Standard)Cat.No.:HY-10396RCASNo.:254750-02-2Synonyms:PF03491390(Standard);IDN-6556(Standard)分?式:C??H??F?N?O?分?量:569.5作?靶點:Caspase;Flavivirus作?通路:Apoptosis;Anti-infection儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Emricasan(Standard)Emricasan的分析標準品。本產品?于研究及分析應?。Emricasan(PF03491390)?種?服有效的不可逆pan-caspase抑制劑。Emricasan抑制Zika病毒(ZIKV)誘導的caspase-3活性增加并保護了?類?層神經祖細胞[1]。IC50&Targetpan-caspase[1]REFERENCES[1].BarreyroFJ,etal.Thepan-caspaseinhibitorEmricasan(IDN-6556)decreasesliverinjuryandfibrosisinamurinemodelofnon-alcoholicsteatohepatitis.LiverInt.2015Mar;35(3):953-66.[2].HoglenNC,etal.CharacterizationofIDN-6556(3-[2-(2-tert-butyl-phenylaminooxalyl)-amino]-propionylamino]-4-oxo-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoicacid):aliver-targetedcaspaseinhibitor.JPharmacolExpTher.2004May;309(2):634-40.[3].McCallM,etal.ThecaspaseinhibitorIDN-6556(PF3491390)improvesmarginalmassengraftmentafterislettransplantationinmice.Surgery.2011Jul;150(1):48-55.[4].TianJ,etal.CombinationofEmricasanwithAP24534SynergisticallyReducesIschemia/ReperfusionInjuryinRatBrainThroughSimultaneousPreventionofApoptosisandNecroptosis.TranslStrokeRes.2017Nov4.[5].Gracia-SanchoJ,etal.EmricasanAmelioratesPortalHypertensionandLiverFibrosisinCirrhoticRatsThroughaHepatocyte-MediatedParacrineMechanism.HepatolCommun.2019Apr22;3(7):987-1000.[6].XuM,etal.Identificationofsmall-moleculeinhibitorsofZikavirusinfectionandinducedneuralcelldeathviaadrugrepurposingscreen.NatMed.2016Oct;22(10):1101-1107.McePdfHeight1/1MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-