Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEAmbroxol-d5Cat.No.:HY-W739944CASNo.:1246818-80-3Synonyms:NA-872-d5分?式:C??H??D?Br?N?O分?量:383.13作?靶點:Isotope-LabeledCompounds;Autophagy;Glycosidase作?通路:Others;Autophagy;MetabolicEnzyme/Protease儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Ambroxol-d5(NA-872-d5)氘代標記的Ambroxol.Ambroxol(NA-872)前體溴??的活性代謝產物，具有強效祛痰作?。Ambroxol?種葡糖腦苷脂酶(GCase)伴侶，可增加葡糖腦苷脂酶的活性。Ambroxol可誘導肺?噬，并有?于帕?森?病和神經性?謝病研究的潛?。體外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-216.[2].VojoDeretic,etal.Enhancementoflunglevelsofantibioticsbyambroxolandbromhexine.ExpertOpinDrugMetabToxicol.2019Mar;15(3):213-218.[3].AnnaMigdalska-Richards,etal.Ambroxoleffectsinglucocerebrosidaseandα-synucleintransgenicmice.AnnNeurol.2016Nov;80(5):766-775.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792ax:021