組胚學(xué)英文版課件CardiovascularSystem組胚學(xué)英文版課件CardiovascularSystem1---Digestivesystem:DigestivetractDigestivegland---Digestivesystem:21.Componentsofdigestivetract---oralcavity---pharynx---esophagus---stomach---smallintestine---largeintestine1.Componentsofdigestivetra32.Generalstructureofdigestivetractmucosa,submucosa,muscularisexterna,adventitia2.Generalstructureofdigest4組胚學(xué)英文版課件Cardiovascular-System51)mucosa

---epithelium:stratifiedsquamousepi.simplecolumnarepi---laminapropria:LCT-compactCT:containmorecellsandfiberBV,LV-capillariesLymphoidTglands:structuresformedbyinvaginationofepi.intolaminapropria---muscularismucosa:athinlayerofSM1)mucosa62)submucosa:moredenseCTsmallarteryandvein,LVglands(esophagusandduodenum)submucosaNplexus:-multipolarN-unmyelinatedNF-function:regulatethecontractofSMandsecretingofgland*Plica:projectionofmucosaandsubmucosa2)submucosa:moredenseCT7Plicamucosa&submucosPlicamucosa&submucos83)muscularisexternasmoothmuscleskeletalmuscleinnercircularandouterlongitudinal*Nerveplexus:regulatethemovementofM4)adventitia:CTserosa:CT+mesotheliumfibrosa:LCT3)muscularisexterna9Nerveplexusbetweenlayersofmuscularis→cellbodyofnervecellsNerveplexusbetweenlayersof10serosafibrosaserosafibrosa11組胚學(xué)英文版課件Cardiovascular-System123.Esophagus

1)

mucosa:epithelium:stratifiedsquamousepi.laminapropria:compactCTmuscularismucosa:longitudinalarrangedSM2)

submucosa:LCTesophagealgland:mucousgland3.Esophagus1)

mucosa133)

muscularis:innercircularandouterlongitudinalupper1/3:skeletalmusclemiddle1/3:mixedofskeletalMandsmoothmusclelower1/3:smoothmuscle4)adventitia:fibrosa3)

muscularis:14CrosssectionHESlide：mucosa&submucosCrosssectionHESlide：mucosa&s15組胚學(xué)英文版課件Cardiovascular-System16BarrettEsophagusisachroniccomplicationofgastroesophagealre?uxdisease(GERD),characterizedbymetaplasiaofthestrati?edsquamousepitheliumoftheloweresophagusintoaspecializedglandularepitheliumwithgobletcells.Andthein?ammatorycells(mainlylymphocytesandplasmacells)arein?ltratingtheconnectivetissue.BarrettEsophagusisachronic17EsophagealCarcinomaisamalignantneoplasmthatstemsfromtheepithelialcellsliningtheinnersurfaceoftheesophagus.Worldwide,squamouscellcarcinomaisthemostcommontypeofesophageal.Pathologicalchangesincludeulcerations,exophyticmasses,andthickeningandnarrowingofthelumen.Thisphotomicrographshowsamoderatelydifferentiatedsquamouscellcarcinomawithfocalkeratinproductioninthecenter,calledakeratinpearl.EsophagealCarcinomaisamali184.Stomach

---dilatedpart---storefoodtemporarily---digestproteinprimarily---absorbpartofwaterandions4.Stomach---dilatedpart19組胚學(xué)英文版課件Cardiovascular-System20GeneralstructureGeneralstructure21組胚學(xué)英文版課件Cardiovascular-System22組胚學(xué)英文版課件Cardiovascular-System23組胚學(xué)英文版課件Cardiovascular-System24StomachMucosa：---plica-longitudinal---shallowditch-gastricarea(2-6mm)---gastricpit-smalldepressionsStomachMucosa：25

Stomach①epithelium:simplecolumnarepisurfacemucouscell:-tallcolumnar-Novoid,basally-located-mucinogengranule-tightjunction-highHCO3-undissolvedmucusStomach①epithelium:simpleco26

Stomach②laminapropria:CTcontainsfibroblast,LC,plasmacell,mastcellandeosinophil,SMgastricgland(fundicgland)-oxynticglandcardiacgland:mucousglandpyloricgland:mucousglandStomach②laminapropria:CT27parietalcell---LM:large,pyramidalorspherical/roundcentrally-locatednucleus/eosinophiliccytoplasmparietalcell28EM:intracellularsecretorycanaliculus-invaginationstubulovesicularsystemmitochondriaEM:29---function:i.

secrethydrochloricacid(HCl)-synthesisprocessesofHCl:inintracellularsecretorycanaliculusH+K+-ATPpump:getH+fromcellCl-channel:getCl-frombloodH++Cl-→HCl(intracellularsecretortcanaliculi)-functionofHCl:HCl↓pepsinogen→pepsinkillthebacterium---function:30組胚學(xué)英文版課件Cardiovascular-System31ii.

secretintrinsicfactor-glycoprotein+VB12→absorptionofVB12ii.

secretintrinsicfactor32a.chiefcellorzymogeniccell---structure:LM:columnarRound,basally-locatedNucleuscytoplasm:/basal-basophilic/apical-zymogengranulesEM:RER,Golgiapparatus---function:secretpepsinogena.chiefcellorzymogenic33組胚學(xué)英文版課件Cardiovascular-System34c.mucousneckcellless,neckpartcolumnarflattened,basally-locatedNpalestaininHEstaind.stemcell:undifferentiatedcelle.endocrinecell

ECLcell:secretinghistamine,promotesecretionofparietalcellDcell:secretingsomatostatin,inhibitthesecretionofparietalcellc.mucousneckcell351.chiefcell2.parietalcell

3.mucousneckcell1.chiefcell36③Muscularismucosa:innercircularandouterlongitudinalarrangedSM2)

submucosa:CTwithBV,LV,Nandfatcell3)

muscularis:thickerinnerobliquemiddlecircularouterlongitudinal4)advantitia:serosa③Muscularismucosa:innercir37GastricUlcer(PepticUlcer)arechronicmucosallesionsthatoccurinthegastro-intestinaltract.Morphologically,pepticulcersareusuallysmall,roundtoovalinshape,lessthan4cmindiameterwithwellde?nedmarginswithoutelevation,andhaveaclean,smoothbase.Thisimageshowsthetransitionfromgastricmucosatoulcer,showinga?brinopurulentsurfacewithunderlyinggranulationtissue.Thegastricmucosashowschronicgastritiswithplasmacellswithinthelaminapropriaandintestinalmetaplasia(notethegobletcells).GastricUlcer(PepticUlcer)a385.Smallintestine---duodenum---jejunum---ileum5.Smallintestine---d39SEMforvillusSEMforvillus40PlicaVillusMicrovilliusCellcoat組胚學(xué)英文版課件Cardiovascular-System41組胚學(xué)英文版課件Cardiovascular-System42組胚學(xué)英文版課件Cardiovascular-System431)

Mucosa---circularplica---intestinalvillus---smallintestinalgland1)

Mucosa44①epithelium:---absorptivecell:

microvilli:striated-border-1-1.4umlong,80nminD,2000-3000-enlargethesurfaceareato30timescellcoat:-0.1-0.5um-enzymes:trypsinogen,amylase-glucoseandproteinenzymes-adiposeSER①epithelium:45---gobletcell---gobletcell46②laminapropria:CT(LC,macrophage,plasmacellandeosinophilandmastcell)a.villus:istheprojectionofepitheliumandlaminapropriaepithelium:absorptivecell,gobletcellandendocrinecelllaminapropria:CTwithcentrallacteal,fenestratedcap.andSM②laminapropria:CT(LC,macro47Striatedborder¢rallacteal*

Striatedborder¢rallact48組胚學(xué)英文版課件Cardiovascular-System49組胚學(xué)英文版課件Cardiovascular-System50b.smallintestinalgland:istheinvaginationofopropriaabsorptivecellgobletcellendocrinecellstemcellPenethcell

b.smallintestinalgland51Penethcell:LM:-pyramidal,basally-located,ingroups-apical:acidophilicG-containdefensin(cryptdin),LysozymeEM:-protein-secretingcellfeatureFunction:relatedtoimmunefunctionPenethcell:52PenethcellPenethcell53組胚學(xué)英文版課件Cardiovascular-System54組胚學(xué)英文版課件Cardiovascular-System55組胚學(xué)英文版課件Cardiovascular-System56③muscularismucosa:SMinnercircularandouterlongitudinal2)

submucosa:CTLargeBVandLVduodenalgland:mucousgland-secretingepidermalgrowthfactor,promotetheepithelialcellproliferationofsmallintestine③muscularismucosa:SMinnerc573)

muscularis:SM,innercircularandouterlongitudinal4)

adventitia:serosaandlessfibrosa3)

muscularis:SM,inner58組胚學(xué)英文版課件Cardiovascular-System59組胚學(xué)英文版課件Cardiovascular-System60PepticDuodenitisisanin?ammatoryprocesscausedbychronicexposureoftheduodenalmucosatoincreasedlevelsofgastricacidandisusuallyfoundinthe?rstportionoftheduodenum,theduodenalbulb..Thisphotomicrographshowsduodenalmucosawithcompletereplacementofthenormalepitheliumwithgobletcellsbygastricfoveolarepithelium.Notethewidened,distortedvilliandincreasedin?ammatorycellswithinthelaminapropria.PepticDuodenitisisanin?amm616.Largeintestine---absorbwaterandions---structurefeature:a.

novillusandnocircularplicab.

well-developedlargeintestinalglandc.

containmoregobletcellsd.

taeniaecoli:longitudinalbundsbagcoli6.Largeintestine---absorbwa62組胚學(xué)英文版課件Cardiovascular-System63ColorectalCancerisamalignantneoplasmofthecolonortherectum.Adenocarcinomaisthemostcommontypeofcoloncancer(98%ofcases.Presentingsymptomsmaybeachangeinbowelhabitsduetobowelobstruction,bloodinthestool,orironde?ciencyanemia.Thisphotomicrographshowsamoderatelydifferentiatedadenocarcinomaofthecolonin?ltratingthemuscularispropria.ColorectalCancerisamaligna64CrohnDiseaseachronicautoimmunein?ammatorydiseaseofthegastrointestinaltractthat