Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemECorinCat.No.:HY-111048CASNo.:1808113-09-8分?式:C??H??N?O?分?量:428.53作?靶點:HistoneDemethylase;HDAC作?通路:Epigenetics;CellCycle/DNADamage儲存?式:4°C,storedundernitrogen*Insolvent:-80°C,6months;-20°C,1month(storedunder

nitrogen)溶解性數據體外實驗DMSO:100mg/mL(233.36mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.3336mL11.6678mL23.3356mL5mM0.4667mL2.3336mL4.6671mL10mM0.2334mL1.1668mL2.3336mL請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(storedundernitrogen)。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。體內實驗請根據您的實驗動物和給藥?式選擇適當的溶解?案。以下溶解?案都請先按照InVitro?式配制澄的儲備液，再依次添加助溶劑：(為保證實驗結果的可靠性，澄的儲備液可以根據儲存條件，適當保存；體內實驗的?作液，建議您現?現配，當天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過程中出現沉淀、析出現象，可以通過加熱和/或超聲的?式助溶)1.請依序添加每種溶劑：10%DMSO>>40%PEG300>>5%Tween-80>>45%salineSolubility:≥2.5mg/mL(5.83mM);Clearsolution2.請依序添加每種溶劑：10%DMSO>>90%cornoilSolubility:≥2.5mg/mL(5.83mM);Clearsolution1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemEBIOLOGICALACTIVITY?物活性Corin組氨酸賴氨酸特異性去甲化酶(LSD1)和組氨酸脫?酰化酶(HDAC)的雙重抑制劑，其對LSD1的Ki(inact)值為110nM，對HDAC1的IC50值為147nM。IC50&TargetIC50:147nM(HDAC1),Ki(inact):110nM(LSD1)[1].體外研究Corinisabletoinhibitthedeacetylationofsemisynthetic,reconstitutednucleosomesbytheCoRESTternarycomplex.CorinshowsirreversibleinhibitionofHDAC1activity.InComparisontoMS-275,corinappearstomorepotently(CorinEC5095nMvs.MS-275EC50420nM)andefficaciouslyinducecellularH3K9acetylation.Interestingly,Corin(1μM)isnon-toxictoprimaryhumanmelanocytesincontrasttoMS-275(1μM)[1].戶使?本產品發表的科研?獻?NatStructMolBiol.2022Nov7.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].KalinJH,etal.TargetingtheCoRESTcomplexwithdualhistonedeacetylaseanddemethylaseinhibitors.NatCommun.2018Jan4;9(1):53.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel: