Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemE(RS)-MCPGCat.No.:HY-100371CASNo.:146669-29-6Synonyms:alpha-MCPG分?式:C??H??NO?分?量:209.2作?靶點:mGluR作?通路:GPCR/GProtein;NeuronalSignaling儲存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實驗1MNaOH:100mg/mL(478.01mM;ultrasonicandadjustpHto10withNaOH)DMSO:6mg/mL(28.68mM;Needultrasonicandwarming)H2O:<0.1mg/mL(ultrasonic;heatto80°C)(insoluble)MassSolvent1mg5mg10mgConcentration制備儲備液1mM4.7801mL23.9006mL47.8011mL5mM0.9560mL4.7801mL9.5602mL10mM0.4780mL2.3901mL4.7801mL請根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲存時，請在6個?內(nèi)使?，-20°C儲存時，請在1個?內(nèi)使?。BIOLOGICALACTIVITY?物活性(RS)-MCPG(alpha-MCPG)?種競爭性和選擇性I/II組代謝型?氨酸受體(mGluR)拮抗劑。(RS)-MCPG阻斷1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemETBS誘導(dǎo)的幼年和新???海馬神經(jīng)元的轉(zhuǎn)變。IC50&TargetgroupI/groupIImGluR[1]體外研究MCPGcanblockgroupI(mGluR1andmGluR5)andgroupIIreceptors(mGluR2andmGluR3)[2].體內(nèi)研究(RS)-MCPG(alpha-MCPG;500μM)blockstheTBS-inducedshiftsinEGABAineitherjuvenileorneonatalneurons[1].Pretreatmentwiththelowdoseof(RS)-MCPG(25nM;i.c.;daily;5days)significantlyattenuatesamphetamine-inducedlocomotoractivityin10-day-oldmaleandfemaleratsofSprague-Dawleydescent[2].戶使?本產(chǎn)品發(fā)表的科研?獻(xiàn)?FrontCellNeurosci.2019Jun25;13:276.Seemorecustomervalidationsonwww.MedChemEREFERENCES[1].YangBetal.RegulationofGABAEquilibriumPotentialbymGluRsinRatHippocampalCA1Neurons.PLoSOne,2015Sep21,10(9):e0138215.[2].FionaYeuk-LunChoi,etal.Theeffectsof(RS)-MCPGonamphetamine-inducedsensitizationinneonatalrats.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-379