Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEROCK2-IN-2Cat.No.:HY-103620CASNo.:1995065-79-6分?式:C??H??N?OS分?量:360.39作?靶點(diǎn):ROCK作?通路:CellCycle/DNADamage;Cytoskeleton;StemCell/Wnt;TGF-beta/Smad儲(chǔ)存?式:Powder-20°C3years4°C2yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:100mg/mL(277.48mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM2.7748mL13.8739mL27.7477mL5mM0.5550mL2.7748mL5.5495mL10mM0.2775mL1.3874mL2.7748mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。體內(nèi)實(shí)驗(yàn)請(qǐng)根據(jù)您的實(shí)驗(yàn)動(dòng)物和給藥?式選擇適當(dāng)?shù)娜芙?案。以下溶解?案都請(qǐng)先按照InVitro?式配制澄的儲(chǔ)備液，再依次添加助溶劑：(為保證實(shí)驗(yàn)結(jié)果的可靠性，澄的儲(chǔ)備液可以根據(jù)儲(chǔ)存條件，適當(dāng)保存；體內(nèi)實(shí)驗(yàn)的?作液，建議您現(xiàn)?現(xiàn)配，當(dāng)天使?；以下溶劑前顯?的百分?指該溶劑在您配制終溶液中的體積占?；如在配制過(guò)程中出現(xiàn)沉淀、析出現(xiàn)象，可以通過(guò)加熱和/或超聲的?式助溶)1.請(qǐng)依序添加每種溶劑：10%DMSO>>90%cornoil1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemESolubility:≥2.5mg/mL(6.94mM);ClearsolutionBIOLOGICALACTIVITY?物活性ROCK2-IN-2?種選擇性ROCK2抑制劑，IC50<1μM。詳細(xì)信息請(qǐng)參考專(zhuān)利?獻(xiàn)US20180093978A1中的化合物A-30。IC50&TargetROCK21μM(IC50)體外研究Rho-associatedproteinkinase(ROCK)isamemberoftheserine-threonineproteinkinasefamily.ROCK,whichexistsintwoisoforms,ROCK1andROCK2,isaneffectormoleculeofRhoA,andtheRhoA/ROCKsignalingpathwayisinvolvedinanumberofcellularfunctions,whichinclude,forexample,actinorganization,celladhesion,cellmigration,andcytokinesis.Inaddition,theRhoA/ROCKsignalingpathwayisinvolvedinregulatingsmoothmusclecontraction.InhibitorsofROCKhavebeenreportedtobeusefulfortreatingmultiplemedicaldisorders,suchasfibrosis,inflammatorydisorders,autoimmunedisorders,andcardiovasculardisorders[1].REFERENCES[1].Aicher,ThomasDaniel,etal.INDAZOLYLTHIADIAZOLAMINESANDRELATEDCOMPOUNDSFORINHIBITIONOFRHO-ASSOCIATEDPROTEINKINASEANDTHETREATMENTOFDISEASE.US20180093978A1.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400