UnitFiveMedicinalChemistry氨排成en在途惰性全部才能，所有組成成DefinitionofMedicinalMedicinalchemistryisbesttobedefinedasaninterdisciplinaryresearchareaincorporatingdifferentbranchesofchemistryandbiologyintheresearchforbetterandnewdrugs.Inotherwords,medicinalchemistryisthescience,whichdealswiththediscoveryanddesignofnewandbettertherapeuticchemicalsanddevelopmentofthesechemicalsintonewmedicinesanddrugs.DevelopmentofMedicinalEarlyestimation,structuraldetermination,andsynthesisofmedicinalagentsofnaturaloriginsynthesisofsimplifiedfragmentsofcomplexdrugmoleculesGoldenage:empiricalAnaridmiddleToxicity,carcinogenicity,LowAnewmolecularbiology,physicalchemistry,physicalorganicchemistry,powerful yticmethodsTheThalidomideandNewDrugsParas.1- HowdoesimmunesystemCanyoufind ogyInaprocesscalledcombinatorialchemistry,alargenumberofsimilarcompoundsinashortperiodoftimearegeneratedandthenarescreenedfortheonesthatcouldhavemedicinalParas.3-Whatisthedifferencebetweencombinatorialchemistryandthemostcommonwayusedtodiscovernewdrugs?Traditionallookingforsignsofadesiredactivityinalmostanything,likediversecollectionsofsyntheticcompoundsorofchemicalsidentifyingaleadmodifyingtheyieldingaAleadcompoundindrugdiscoveryisachemicalcompoundthathaspharmacologicalorbiologicalactivityandwhosechemicalstructureisusedasastartingpointforchemicalmodificationsinordertoimprovepotency,selectivity,orpharmacokineticparameters.

metabolitesfromnaturalEnjoya cliptoknowmoreaboutcombinatorialchemistry.Whatarethetwobasiccombinatorialtechniquesdrug-makersuseinthistext?ParallelPara.WhoisH.MarioGeysen?AndwhatishisH.MarioGeysenisaresearchscientistatGlaxo eInc. (GSK)(葛蘭素 )wasestablishedinDec.,2000bycombiningeInc.andSmithasheetofmoldedplasticthattypicallycontainseightrowsand12columnsoftinywells，eachofwhichholdsafewmillilitersoftheliquidinwhichthereactionswilloccur.(Para.7)Chemistsoftenstartsacombinatorialsynthesisbyattachingthefirstsetofbuildingblockstoinert,microscopicbeadsmadeofpolystyrene(oftenreferredtoassolidsupport).(Para.8)Inert,microscopic聚苯乙solid固體載Parallelsynthesis: tripeptidesfrom3aminoacids 2727Split-and-mixSynthesis: Synthesisofallpossibletripeptidesusing3amino No.of

No.of

273Split-and-mixAdvantages:reducethenumberofvessels;incr