Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENSAHCat.No.:HY-114503CASNo.:1099592-35-4分?式:C??H??N?O?分?量:306.32作?靶點(diǎn):DNA/RNASynthesis作?通路:CellCycle/DNADamage儲(chǔ)存?式:Powder-20°C3yearsInsolvent-80°C6months-20°C1month溶解性數(shù)據(jù)體外實(shí)驗(yàn)DMSO:62.5mg/mL(204.03mM;Needultrasonic)MassSolvent1mg5mg10mgConcentration制備儲(chǔ)備液1mM3.2646mL16.3228mL32.6456mL5mM0.6529mL3.2646mL6.5291mL10mM0.3265mL1.6323mL3.2646mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度選擇合適的溶劑配制儲(chǔ)備液；?旦配成溶液，請(qǐng)分裝保存，避免反復(fù)凍融造成的產(chǎn)品失效。儲(chǔ)備液的保存?式和期限：-80°C,6months;-20°C,1month。-80°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?，-20°C儲(chǔ)存時(shí)，請(qǐng)?jiān)?個(gè)?內(nèi)使?。BIOLOGICALACTIVITY?物活性NSAH可逆的、競(jìng)爭(zhēng)性的?核苷類的核苷酸還原酶(RR)的抑制劑，其cell-free和cell-bases的IC50值分別為32μM和~250nM。體外研究NSAHdepressesdGTPanddATPlevelsinthedNTPpoolcausingS-phasearrest,providingevidenceforRRinhibitionincells[1].NSAH(0-10μM,2,6,24,or72h)exhibitspotentanti-tumoractivityin3cancercelllines[1].1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemENSAHblocksS-phaseprogressionwelltotheextentandtimingofthedecreasesindATPanddGTP[1].CellViabilityAssay[1]CellLine:MDA-231,HCT116andPanc1cancercelllines.Concentration:0-10μM.IncubationTime:2,6,24,or72h.Result:ResultedinIC50valuesrangingfrom220to500nM.REFERENCES[1].MdFaizAhmad,etal.Potentcompetitiveinhibitionofhumanribonucleotidereductasebyanonnucleosidesmallmolecule.ProcNatlAcadSciUSA.2017Aug1;114(31):8241-8246.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792/p>