1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEIsoginkgetinCat. No.: HY-N2117CAS No.: 548-19-6分式: CHO分量: 566.51作靶點: MMP作通路: Metabolic Enzyme/Protease儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數據體外實驗 DMSO : 83.3 mg/mL (147.04 mM)* means soluble,

2、but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 1.7652 mL 8.8260 mL 17.6519 mL5 mM 0.3530 mL 1.7652 mL 3.5304 mL10 mM 0.1765 mL 0.8826 mL 1.7652 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗 請根據您的實驗動物和給藥式選擇適當的溶解案，配制前請先配制澄清的儲備液，再依次添加助溶劑(為保證實驗結果的可靠性，體內實驗的作液，建議您現現配，當天使；澄清

3、的儲備液可以根據儲存條件，適當保存；以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 2.08 mg/mL (3.67 mM); Clear solutionBIOLOGICAL ACTIVITY1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE物活性 Isoginkgetin是MMP9的抑制劑，也是Pre-mRNA Splicing的抑制劑。REFERENCES1. Yoon SO et al. Isogi

4、nkgetin inhibits tumor cell invasion by regulating phosphatidylinositol 3-kinase/Akt-dependent matrixmetalloproteinase-9 expression. Mol Cancer Ther. 2006 Nov;5(11):2666-75.2. OBrien K et al. The biflavonoid isoginkgetin is a general inhibitor of Pre-mRNA splicing. J Biol Chem. 2008 Nov 28;283(48):3

5、3147-54.3. Liu G et al. Isoginkgetin enhances adiponectin secretion from differentiated adiposarcoma cells via a novel pathway involving AMP-activated protein kinase.J Endocrinol. 2007 Sep;194(3):569-78.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-5895