1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEAcebilustatCat. No.: HY-17625CAS No.: 943764-99-6Synonyms: CTX-4430分式: CHNO分量: 481.54作靶點: Others作通路: Others儲存式: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數據體外實驗 DMSO : 16.67 mg/mL (34.62 mM; Need ultras

2、onic)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 2.0767 mL 10.3834 mL 20.7667 mL5 mM 0.4153 mL 2.0767 mL 4.1533 mL10 mM 0.2077 mL 1.0383 mL 2.0767 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注意儲備液的保存式和期限。體內實驗請根據您的實驗動物和給藥式選擇適當的溶解案，配制前請先配制澄清的儲備液，再依次添加助溶劑(為保證實驗結果的可靠性，體內實驗的作液，建議您現現配，當天使；澄清的儲備液可以根據儲存條件，適當保存；

3、以下溶劑前的百分 指該溶劑在您配制終溶液中的體積占)：1. 請依序添加每種溶劑： 10% DMSO 40% PEG300 5% Tween-80 45% salineSolubility: 1.67 mg/mL (3.47 mM); Clear solution2. 請依序添加每種溶劑： 10% DMSO 90% (20% SBE-CD in saline)Solubility: 1.67 mg/mL (3.47 mM); Clear solution3. 請依序添加每種溶劑： 10% DMSO 90% corn oil1/2 Master of Small Molecules 您邊的抑制劑師

4、www.MedChemESolubility: 1.67 mg/mL (3.47 mM); Clear solutionBIOLOGICAL ACTIVITY物活性 Acebilustat (CTX-4430)種可服的三烯 A4 解酶抑制劑，于炎癥治療。體外研究 Acebilustat (CTX-4430) is a leukotriene A4 hydrolase inhibitor, which is safe and well tolerated in phase 1trial 1. Acebilustat is an antiinflammatory drug in developme

5、nt for the treatment of CF and other diseases. Itis a potent inhibitor of the enzyme leukotriene A4 hydrolase (LTA4H), which catalyzes the rate-limiting step inthe formation of leukotriene B4 (LTB4), a potent chemoattractant and activator of inflammatory immune cellsincluding neutrophils 2.REFERENCE

6、S1. Elborn JS, et al. Phase 1 Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis. Clin Transl Sci. 2016Nov 22. Elborn JS, et al. Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction. Clin TranslSci. 2016 Oct 28.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 40