Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEEtazolatehydrochloride(Standard)Cat.No.:HY-100936RCASNo.:35838-58-5Synonyms:SQ20009(Standard);EHT0202hydrochloride(Standard)分?式:C??H??ClN?O?分?量:325.79作?靶點:Phosphodiesterase(PDE);GABAReceptor作?通路:MetabolicEnzyme/Protease;MembraneTransporter/IonChannel;NeuronalSignaling儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Etazolate(hydrochloride)(Standard)Etazolate(hydrochloride)的分析標準品。本產品?于研究及分析應?。Etazolatehydrochloride(SQ20009)?種?服有效的、選擇性的4型磷酸?酯酶(PDE4)抑制劑，IC50為2μM。Etazolatehydrochloride?種γ-氨丁酸A(GABAA)受體調節(jié)劑。Etazolatehydrochloride是?種α-分泌酶(α-secretase)激活劑，可誘導可溶性淀粉樣前體蛋?(sAPPα)的產?。Etazolatehydrochloride?種吡唑并吡啶類衍?物，可增加cAMP?平。Etazolatehydrochloride具有抗焦慮樣、抗抑郁樣和抗炎作?。REFERENCES[1].XuemeiWei,etal.Targetingphosphodiesterase4asatherapeuticstrategyforcognitiveimprovement.BioorgChem.2023Jan;130:106278.[2].ArijitBhattacharya,etal.RoleofadifferentiallyexpressedcAMPphosphodiesteraseinregulatingtheinductionofresistanceagainstoxidativedamageinLeishmaniadonovani.FreeRadicBiolMed.2009Nov15;47(10):1494-506.[3].EleniSiopi,etal.Etazolate,anα-secretaseactivator,reducesneuroinflammationandofferspersistentneuroprotectionfollowingtraumaticbraininjuryinmice.Neuropharmacology.2013Apr;67:183-92.[4].AnkurJindal,etal.Etazolate,aphosphodiesterase4inhibitorreverseschronicunpredictablemildstress-induceddepression-likebehaviorandbrainoxidativedamage.PharmacolBiochemBehav.2013Apr;105:63-70.[5].AnkurJindal,etal.Antidepressant-likeeffectofetazolate,acyclicnucleotidephosphodiesterase4inhibitor--anapproachusingrodentbehavioralantidepressanttestsbattery.EurJPharmacol.2012Aug15;689(1-3):125-31.McePdfHeight1/1MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400