Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemESitaxsentan-13C6Cat.No.:HY-76520SSynonyms:IPI1040-13C6;TBC-11251-13C6分?式:C????C?H??ClN?O?S?分?量:458.84作?靶點(diǎn):Isotope-LabeledCompounds;EndothelinReceptor作?通路:Others;GPCR/GProtein儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Sitaxsentan-13C6(IPI1040-13C6)13C標(biāo)記的Sitaxsentan.Sitaxsentan(IPI1040;TBC-11251)選擇性內(nèi)?素A(ETA)受體拮抗劑。體外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-216.[2].ChinM,LevyRD,YoshidaEM,ByrneMF.Sitaxsentan-inducedacuteseverehepatitistreatedwithglucocorticoidtherapy.CanRespirJ.2012Jan-Feb;19(1):e1-2.[3].SandovalJ,etal.STRIDE-4investigators.Safetyandefficacyofsitaxsentan50and100mginpatientswithpulmonaryarterialhypertension.PulmPharmacolTher.2012Feb;25(1):33-9.Epub2011Nov2.[4].SafdarZ.Effectoftransitionfromsitaxsentantoambrisentaninpulmonaryarterialhypertension.VascHealthRiskManag.2011;7:119-24.Epub2011Mar2.[5].RondeletB,etal.Sildenafiladdedtositaxsentaninovercirculation-inducedpulmonaryarterialhypertension.AmJPhysiolHeartCircPhysiol.2010Oct;299(4):H1118-23.Epub2010Aug6.[6].Kaehler,etal.SuccessfultreatmentofportopulmonaryhypertensionwiththeselectiveendothelinreceptorantagonistSitaxentan.WienKlinWochenschr.2011Apr;123(7-8):248-52.Epub2011Mar31.McePdfHeight1/1MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-8