Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemEBAY60-6583(Standard)Cat.No.:HY-103171RCASNo.:910487-58-0分?式:C??H??N?O?S分?量:379.44作?靶點(diǎn):AdenosineReceptor作?通路:GPCR/GProtein儲(chǔ)存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性BAY60-6583(Standard)BAY60-6583的分析標(biāo)準(zhǔn)品。本產(chǎn)品?于研究及分析應(yīng)?。BAY60-6583腺苷A2B受體的?效選擇性激動(dòng)劑，對(duì)A2B受體(EC50=3nM)的選擇性?于A1，A2A和A3受體。BAY60-6583可以與??，兔和狗A2BAR結(jié)合，Ki值分別為750nM，340nM和330nM。BAY60-6583在?肌缺?模型中具有?臟保護(hù)作?。REFERENCES[1].AherneCM,etal.Epithelial-specificA2Badenosinereceptorsignalingprotectsthecolonicepithelialbarrierduringacutecolitis.MucosalImmunol.2015Nov;8(6):1324-38.[2].SchingnitzU,etal.SignalingthroughtheA2Badenosinereceptordampensendotoxin-inducedacutelunginjury.JImmunol.2010May1;184(9):5271-9.[3].GaoZG,etal.Probingbiased/partialagonismattheGprotein-coupledA(2B)adenosinereceptor.BiochemPharmacol.2014Aug1;90(3):297-306.[4].YoonTaekOh,etal.A2BAdenosineReceptorStimulationDown-regulatesM-CSF-mediatedOsteoclastProliferation.BiomedSciLetters2017;23:194-200[5].JohnA.Auchampach,etal.CharacterizationoftheA2BAdenosineReceptorfromMouse,Rabbit,andDog.JPharmacolExpTher.2009Apr;329(1):2-13.[6].MorelloS1,etal.TargetingtheadenosineA2breceptorinthetumormicroenvironmentovercomeslocalimmunosuppressionbymyeloid-derivedsuppressorcells.Oncoimmunology.2014Feb14;3:e27989.eCollection2014.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955