Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemERiboflavin-d8Cat.No.:HY-B0456S5Synonyms:VitaminB2-d8;E101-d8分?式:C??H??D?N?O?分?量:384.41作?靶點:Isotope-LabeledCompounds;Bacterial;EndogenousMetabolite作?通路:Others;Anti-infection;MetabolicEnzyme/Protease儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Riboflavin-d8(VitaminB2-d8)氘代標記的Riboflavin.Riboflavin?種具有?服活性且極易吸收的微量營養素，素單核苷酸（FMN）和素腺嘌呤?核苷酸（FAD）的前體，Riboflavin作為多種酶促反應的輔酶，并通過介導?物氧化還原反應中的電?轉移來執?關鍵的代謝功能[1]。體外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-216.[2].ThakurK,etal.Riboflavinandhealth:Areviewofrecenthumanresearch.CritRevFoodSciNutr.2017Nov22;57(17):3650-3660.[3].deSouzaAC,etal.Apromisingactionofriboflavinasamediatorofleukaemiacelldeath.Apoptosis.2006Oct;11(10):1761-71.[4].XinZ,etal.RiboflavindeficiencyinducesasignificantchangeinproteomicprofilesinHepG2cells.SciRep.2017Apr3;7:45861.[5].AgteVV,etal.Effectofriboflavinsupplementationonzincandironabsorptionandgrowthperformanceinmice.BiolTraceElemRes.1998Nov;65(2):109-15.[6].Granados-SotoV,etal.Riboflavinreduceshyperalgesiaandinflammationbutnottactileallodyniaintherat.EurJPharmacol.2004May10;492(1):35-40.[7].Fran?aDS,etal.Bvitaminsinduceanantinociceptiveeffectintheaceticacidandformaldehydemodelsofnociceptioninmice.EurJPharmacol.2001Jun15;421(3):157-64.McePdfHeight1/1MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemECaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:40