Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemELevodropropizine-d5Cat.No.:HY-B1895S1Synonyms:(S)-(-)-Dropropizine-d5;DF-526-d5分?式:C??H??D?N?O?分?量:241.34作?靶點:Isotope-LabeledCompounds;HistamineReceptor作?通路:Others;GPCR/GProtein;Immunology/Inflammation;NeuronalSignaling儲存?式:PleasestoretheproductundertherecommendedconditionsintheCertificateofAnalysis.BIOLOGICALACTIVITY?物活性Levodropropizine-d5((S)-(-)-Dropropizine-d5)氘代標記的Levodropropizine.Levodropropizine(DF-526)?種具有?服活性的組胺受體抑制劑。Levodropropizine?種有效的,良好耐受性的鎮咳劑。體外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattentionbecauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.REFERENCES[1].RussakEM,etal.ImpactofDeuteriumSubstitutiononthePharmacokineticsofPharmaceuticals.AnnPharmacother.2019;53(2):211-216.[2].LuoYL,etal.Effectsoffourantitussivesonairwayneurogenicinflammationinaguineapigmodelofchroniccoughinducedbycigarettesmokeexposure.InflammRes.2013Dec;62(12):1053-61.[3].ErdoganMA,etal.Levodropropizinesuppressesseizureactivityinratswithpentylenetetrazol-inducedepilepsy.EpilepsyRes.2019Feb;150:32-37.[4].YamawakiI,etal.Levodropropizinereducescapsaicin-andsubstanceP-inducedplasmaextravasationintherattrachea.EurJPharmacol.1993Oct12;243(1):1-6.[5].ZanasiA,etal.Levodropropizinefortreatingcoughinadultandchildren:ameta-analysisofpublishedstudies.MultidiscipRespirMed.2015May31;10(1):19.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;02