Hotline:400-820-3792Inhibitors?ScreeningLibraries?Proteinswww.MedChemENitrocaramiphenhydrochlorideCat.No.:HY-100945CASNo.:98636-73-8分?式:C??H??ClN?O?分?量:370.87作?靶點:mAChR作?通路:GPCR/GProtein;NeuronalSignaling儲存?式:-20°C,sealedstorage,awayfrommoisture*Insolvent:-80°C,6months;-20°C,1month(sealed

storage,awayfrommoisture)溶解性數據體外實驗H2O:8.33mg/mL(22.46mM;ultrasonicandwarmingandheatto60°C)MassSolvent1mg5mg10mgConcentration制備儲備液1mM2.6964mL13.4818mL26.9636mL5mM0.5393mL2.6964mL5.3927mL10mM0.2696mL1.3482mL2.6964mL請根據產品在不同溶劑中的溶解度選擇合適的溶劑配制儲備液；?旦配成溶液，請分裝保存，避免反復凍融造成的產品失效。儲備液的保存?式和期限：-80°C,6months;-20°C,1month(sealedstorage,awayfrommoisture)。-80°C儲存時，請在6個?內使?，-20°C儲存時，請在1個?內使?。BIOLOGICALACTIVITY?物活性NitrocaramiphenHydrochloride?種選擇性M1受體拮抗劑(Ki:5.5nM)。NitrocaramiphenHydrochloride抑制肌纖維中毒蕈堿的超極化作?。IC50&TargetKi:5.5nM(M1receptor)[2]REFERENCES1/2MasterofBioactiveMolecules—您?邊的抑制劑?師www.MedChemE[1].HussainRI,etal.Activationofmuscarinicreceptorselicitsinotropicresponsesinventricularmusclefromratswithheartfailurethroughmyosinlightchainphosphorylation.BrJPharmacol.2009Feb;156(4):575-86.[2].HudkinsRL,etal.Caramiphen,iodocaramiphenandnitrocaramiphenarepotent,competitive,muscarinicM1receptor-selectiveagents.EurJPharmacol.1993Feb16;231(3):485-8.[3].NaumenkoNV,etal.[Pharmacologicalparametersofmuscariniccholinoreceptorsinskeletalmuscles].RossFiziolZhImIMSechenova.2002May;88(5):619-26.McePdfHeightCaution:Producthasnotbeenfullyvalidatedformedicalapplications.Forresearchuseonly.Tel:400-820-3792;021-58955