1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemECromolyn sodiumCat. No.: HY-B0320ACAS No.: 15826-37-6Synonyms: Disodium Cromoglycate; FPL-670分式: CHNaO分量: 512.33作靶點(diǎn): Calcium Channel; GSK-3作通路: Membrane Transporter/Ion Channel; Neuronal Signaling;PI3K/Akt/mTOR; Stem Cell/Wnt儲(chǔ)存式

2、: Powder -20C 3 years4C 2 yearsIn solvent -80C 6 months-20C 1 month溶解性數(shù)據(jù)體外實(shí)驗(yàn) H2O : 32 mg/mL (62.46 mM)* means soluble, but saturation unknown.Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 1.9519 mL 9.7593 mL 19.5187 mL5 mM 0.3904 mL 1.9519 mL 3.9037 mL10 mM 0.1952 mL 0.9759 mL 1.9519 mL請(qǐng)根據(jù)產(chǎn)品在不同

3、溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。體內(nèi)實(shí)驗(yàn) Cromolyn sodium is dissolved in PBS3.BIOLOGICAL ACTIVITY物活性 Cromolyn sodium抗過(guò)敏化合物。Cromolyn sodium 種 GSK-3 抑制劑，IC50 為 2.0 M。1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemEIC50 & Target GSK-32 M (IC50)體外研究 Cromolyn (sodium) is a chromone complex that acts by

4、inhibiting the release of chemical mediators fromsensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma,but does not affect an established asthmatic attack.體內(nèi)研究 Pretreatment of IIR mice with Cromolyn (sodium) prior to ischemia exhibited no change

5、s of ET-1 levels, injuryscore and inflammation (P0.05, PreCr vs. M groups). In conclusion, administration of Cromolyn (sodium)after reperfusion, but not prior to ischemia, attenuates IIRI by downregulating ET-1 and suppressingsustained MC activation 1. Cromolyn (sodium) has a role in the prevention

6、of Chronic lung disease(CLD).Cromolyn (sodium) cannot be recommended for the prevention of CLD in preterm infants 2.戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Pharmacol Res. 2017 Nov;125(Pt B):150-160.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Gan, X., et al., Treatment of mice with cromolyn sodium afte

7、r reperfusion, but not prior to ischemia, attenuates small intestinal ischemia-reperfusion injury. Mol Med Rep, 2013. 8(3): p. 928-34.2. Ng, G. and A. Ohlsson, Cromolyn sodium for the prevention of chronic lung disease in preterm infants. Cochrane Database Syst Rev,2012. 6: p. CD003059.3. Huang L, et al. Sinomenine-induced histamine release-like anaphylactoid reactions are blocked by tranilast via inhibiting NF-Bsignaling. Pharmacol Res. 2017 Aug 31. pii: S1043-6618(17)30796-X.McePdfHeightCaution: Product has not been fully validated for medical applications.For r