1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemEDacarbazineCat. No.: HY-B0078CAS No.: 4342-03-4Synonyms: Imidazole Carboxamide分式: CHNO分量: 182.18作靶點: Nucleoside Antimetabolite/Analog作通路: Cell Cycle/DNA Damage儲存式: 4C, protect from light* In solvent : -80C, 6 months; -20C, 1 mon

2、th (protect fromlight)溶解性數據體外實驗 DMSO : 6.42 mg/mL (35.24 mM; Need ultrasonic and warming)H2O : 0.1 mg/mL (insoluble)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲備液1 mM 5.4891 mL 27.4454 mL 54.8908 mL5 mM 1.0978 mL 5.4891 mL 10.9782 mL10 mM 0.5489 mL 2.7445 mL 5.4891 mL請根據產品在不同溶劑中的溶解度，選擇合適的溶劑配制儲備液，并請注

3、意儲備液的保存式和期限。BIOLOGICAL ACTIVITY物活性 Dacarbazine(DTIC-Dome; DTIC)有抗素瘤活性。戶使本產品發表的科研獻 J Mol Med (Berl). 2019 Jun 14.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemESee more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Serrone, L., et al., Dacarbazine-based chemotherapy for metastatic me

4、lanoma: thirty-year experience overview. J Exp Clin Cancer Res,2000. 19(1): p. 21-34.2. Ramanathan, R.K., et al., Phase II trial of dacarbazine (DTIC) in advanced pancreatic islet cell carcinoma. Study of the EasternCooperative Oncology Group-E6282. Ann Oncol, 2001. 12(8): p. 1139-43.3. Middleton, M

5、.R., et al., Randomized phase III study of temozolomide versus dacarbazine in the treatment of patients with advancedmetastatic malignant melanoma. J Clin Oncol, 2000. 18(1): p. 158-66.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792; 021-58955