1、Hotline: 400-820-3792Inhibitors Agonists Screening Librarieswww.MedChemE7ACC1Cat. No.: HY-D0067CAS No.: 50995-74-9Synonyms: DEAC; Coumarin D 1421; D 1421分式: CHNO分量: 261.27作靶點(diǎn): Monocarboxylate Transporter作通路: Membrane Transporter/Ion Channel儲(chǔ)存式: 4C, protect from light* In solvent : -80C, 6 months; -2

2、0C, 1 month (protect fromlight)溶解性數(shù)據(jù)體外實(shí)驗(yàn) DMSO : 32 mg/mL (122.48 mM; Need ultrasonic and warming)Mass Solvent1 mg 5 mg 10 mg Concentration制備儲(chǔ)備液1 mM 3.8275 mL 19.1373 mL 38.2746 mL5 mM 0.7655 mL 3.8275 mL 7.6549 mL10 mM 0.3827 mL 1.9137 mL 3.8275 mL請(qǐng)根據(jù)產(chǎn)品在不同溶劑中的溶解度，選擇合適的溶劑配制儲(chǔ)備液，并請(qǐng)注意儲(chǔ)備液的保存式和期限。BIOLOGIC

3、AL ACTIVITY物活性 7ACC1(DEAC; Coumarin D 1421; D 1421)能選擇性擾腫瘤微環(huán)境乳酸通量，能抑制表達(dá)MCT1和MCT4腫瘤細(xì)胞的乳酸涌，但對(duì)乳酸流出影響。戶使本產(chǎn)品發(fā)表的科研獻(xiàn) Cancer Cell Int. 2019 Jun.1/2 Master of Small Molecules 您邊的抑制劑師www.MedChemE Cancer Med. 2018 Sep;7(9):4690-4700.See more customer validations on HYPERLINK / www.MedChemEREFERENCES1. Draoui N

4、, et al. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux.Mol Cancer Ther. 2014 Jun;13(6):1410-8.McePdfHeightCaution: Product has not been fully validated for medical applications.For research use only.Tel: 400-820-3792;Fax: 021-53